Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Differentiated neurons established via iPSCs from patients that suffer from familial Parkinson’s disease (PD) have allowed insights into the mechanisms of neurodegeneration. In the larger cohort of patients with sporadic PD, iPSC based information on disease specific cellular phenotypes is rare. We...

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Detalles Bibliográficos
Autores principales: Schulze, Markus, Sommer, Annika, Plötz, Sonja, Farrell, Michaela, Winner, Beate, Grosch, Janina, Winkler, Jürgen, Riemenschneider, Markus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038190/
https://www.ncbi.nlm.nih.gov/pubmed/29986767
http://dx.doi.org/10.1186/s40478-018-0561-x

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