Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

BACKGROUND: Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. METHODS: We examined the molecular and functional effects of single and...

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Detalles Bibliográficos
Autores principales: Del Curatolo, Anais, Conciatori, Fabiana, Cesta Incani, Ursula, Bazzichetto, Chiara, Falcone, Italia, Corbo, Vincenzo, D’Agosto, Sabrina, Eramo, Adriana, Sette, Giovanni, Sperduti, Isabella, De Luca, Teresa, Marabese, Mirko, Shirasawa, Senji, De Maria, Ruggero, Scarpa, Aldo, Broggini, Massimo, Del Bufalo, Donatella, Cognetti, Francesco, Milella, Michele, Ciuffreda, Ludovica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038340/
https://www.ncbi.nlm.nih.gov/pubmed/29986755
http://dx.doi.org/10.1186/s13046-018-0820-5

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