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Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis
Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038491/ https://www.ncbi.nlm.nih.gov/pubmed/30046309 http://dx.doi.org/10.1155/2018/3472087 |
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author | Sachdev, Prageet K. Freeland-Graves, Jeanne Beretvas, S. Natasha Sanjeevi, Namrata |
author_facet | Sachdev, Prageet K. Freeland-Graves, Jeanne Beretvas, S. Natasha Sanjeevi, Namrata |
author_sort | Sachdev, Prageet K. |
collection | PubMed |
description | Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclusion criteria. The standardized mean difference was utilized as the effect size. The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis. There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients. The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features. |
format | Online Article Text |
id | pubmed-6038491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60384912018-07-25 Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis Sachdev, Prageet K. Freeland-Graves, Jeanne Beretvas, S. Natasha Sanjeevi, Namrata Int J Dent Review Article Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclusion criteria. The standardized mean difference was utilized as the effect size. The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis. There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients. The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features. Hindawi 2018-06-26 /pmc/articles/PMC6038491/ /pubmed/30046309 http://dx.doi.org/10.1155/2018/3472087 Text en Copyright © 2018 Prageet K. Sachdev et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sachdev, Prageet K. Freeland-Graves, Jeanne Beretvas, S. Natasha Sanjeevi, Namrata Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title_full | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title_fullStr | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title_full_unstemmed | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title_short | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
title_sort | zinc, copper, and iron in oral submucous fibrosis: a meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038491/ https://www.ncbi.nlm.nih.gov/pubmed/30046309 http://dx.doi.org/10.1155/2018/3472087 |
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