Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections

Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis...

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Autores principales: Tsai, Wen-Yang, Youn, Han Ha, Tyson, Jasmine, Brites, Carlos, Tsai, Jih-Jin, Pedroso, Celia, Drexler, Jan Felix, Balmaseda, Angel, Harris, Eva, Wang, Wei-Kung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038735/
https://www.ncbi.nlm.nih.gov/pubmed/29912689
http://dx.doi.org/10.3201/eid2407.171170
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author Tsai, Wen-Yang
Youn, Han Ha
Tyson, Jasmine
Brites, Carlos
Tsai, Jih-Jin
Pedroso, Celia
Drexler, Jan Felix
Balmaseda, Angel
Harris, Eva
Wang, Wei-Kung
author_facet Tsai, Wen-Yang
Youn, Han Ha
Tyson, Jasmine
Brites, Carlos
Tsai, Jih-Jin
Pedroso, Celia
Drexler, Jan Felix
Balmaseda, Angel
Harris, Eva
Wang, Wei-Kung
author_sort Tsai, Wen-Yang
collection PubMed
description Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis, serosurveillance, and monitoring of Zika complications in dengue-endemic regions.
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spelling pubmed-60387352018-07-11 Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections Tsai, Wen-Yang Youn, Han Ha Tyson, Jasmine Brites, Carlos Tsai, Jih-Jin Pedroso, Celia Drexler, Jan Felix Balmaseda, Angel Harris, Eva Wang, Wei-Kung Emerg Infect Dis Dispatch Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis, serosurveillance, and monitoring of Zika complications in dengue-endemic regions. Centers for Disease Control and Prevention 2018-07 /pmc/articles/PMC6038735/ /pubmed/29912689 http://dx.doi.org/10.3201/eid2407.171170 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Tsai, Wen-Yang
Youn, Han Ha
Tyson, Jasmine
Brites, Carlos
Tsai, Jih-Jin
Pedroso, Celia
Drexler, Jan Felix
Balmaseda, Angel
Harris, Eva
Wang, Wei-Kung
Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title_full Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title_fullStr Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title_full_unstemmed Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title_short Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections
title_sort use of urea wash elisa to distinguish zika and dengue virus infections
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038735/
https://www.ncbi.nlm.nih.gov/pubmed/29912689
http://dx.doi.org/10.3201/eid2407.171170
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