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Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5′-phosphopantetheine prosthetic group plays a key role in delivering acy...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038798/ https://www.ncbi.nlm.nih.gov/pubmed/28980673 http://dx.doi.org/10.1039/c7cc04625a |