Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits mammalian target of rapamycin complex 1 (mTORC1) in response to amino acid insufficiency. Here, we show that loss of NPRL2 and GATOR1 function in skeletal muscle causes constitutive activation of mTORC1 signaling in the fed and f...

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Detalles Bibliográficos
Autores principales: Dutchak, Paul A., Estill-Terpack, Sandi J., Plec, Abigail A., Zhao, Xiaozheng, Yang, Chendong, Chen, Jun, Ko, Bookyung, Deberardinis, Ralph J., Yu, Yonghao, Tu, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038807/
https://www.ncbi.nlm.nih.gov/pubmed/29768191
http://dx.doi.org/10.1016/j.celrep.2018.04.058

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