The abnormal activation of D1R/Shp-2 complex involved in levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats

BACKGROUND: Levodopa-induced dyskinesia (LID) is a troublesome problem in the treatment of Parkinson’s disease (PD). The mechanisms of LID are still mysterious. Recently, the interaction between Shp-2 and D1 dopamine receptor (D1R) has been identified to be indispensable in the D1R-mediated extracel...

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Detalles Bibliográficos
Autores principales: Wu, Na, Wan, Ying, Song, Lu, Qi, Chen, Liu, Zhenguo, Gan, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038854/
https://www.ncbi.nlm.nih.gov/pubmed/30013350
http://dx.doi.org/10.2147/NDT.S162562

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