Cargando…
Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
BACKGROUND: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuN...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038872/ https://www.ncbi.nlm.nih.gov/pubmed/30013346 http://dx.doi.org/10.2147/IJN.S154555 |
_version_ | 1783338583567892480 |
---|---|
author | Smilowitz, Henry M Meyers, Alexandria Rahman, Khalil Dyment, Nathaniel A Sasso, Dan Xue, Crystal Oliver, Douglas L Lichtler, Alexander Deng, Xiaomeng Ridwan, Sharif M Tarmu, Lauren J Wu, Qian Salner, Andrew L Bulsara, Ketan R Slatkin, Daniel N Hainfeld, James F |
author_facet | Smilowitz, Henry M Meyers, Alexandria Rahman, Khalil Dyment, Nathaniel A Sasso, Dan Xue, Crystal Oliver, Douglas L Lichtler, Alexander Deng, Xiaomeng Ridwan, Sharif M Tarmu, Lauren J Wu, Qian Salner, Andrew L Bulsara, Ketan R Slatkin, Daniel N Hainfeld, James F |
author_sort | Smilowitz, Henry M |
collection | PubMed |
description | BACKGROUND: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might be an alternative mode of delivery. MATERIALS AND METHODS: Using the advanced, invasive, and difficult-to-treat F98 rat glioma model, we have studied the biodistribution of the AuNPs in the tumor and surrounding brain after either IV injection or direct intratumoral infusion by convection-enhanced delivery using light microscopy immunofluorescence and direct gold visualization. RESULTS: IV-injected AuNPs localize more specifically to intracerebral tumor cells, both in the main tumor mass and in the migrated tumor cells as well as the tumor edema, than do the directly infused AuNPs. Although some of the directly infused AuNPs do access the main tumor region, such access is largely restricted. CONCLUSION: These data suggest that IV-injected AuNPs are likely to have a greater therapeutic benefit when combined with radiation therapy than after the direct infusion of AuNPs. |
format | Online Article Text |
id | pubmed-6038872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60388722018-07-16 Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery Smilowitz, Henry M Meyers, Alexandria Rahman, Khalil Dyment, Nathaniel A Sasso, Dan Xue, Crystal Oliver, Douglas L Lichtler, Alexander Deng, Xiaomeng Ridwan, Sharif M Tarmu, Lauren J Wu, Qian Salner, Andrew L Bulsara, Ketan R Slatkin, Daniel N Hainfeld, James F Int J Nanomedicine Original Research BACKGROUND: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might be an alternative mode of delivery. MATERIALS AND METHODS: Using the advanced, invasive, and difficult-to-treat F98 rat glioma model, we have studied the biodistribution of the AuNPs in the tumor and surrounding brain after either IV injection or direct intratumoral infusion by convection-enhanced delivery using light microscopy immunofluorescence and direct gold visualization. RESULTS: IV-injected AuNPs localize more specifically to intracerebral tumor cells, both in the main tumor mass and in the migrated tumor cells as well as the tumor edema, than do the directly infused AuNPs. Although some of the directly infused AuNPs do access the main tumor region, such access is largely restricted. CONCLUSION: These data suggest that IV-injected AuNPs are likely to have a greater therapeutic benefit when combined with radiation therapy than after the direct infusion of AuNPs. Dove Medical Press 2018-07-04 /pmc/articles/PMC6038872/ /pubmed/30013346 http://dx.doi.org/10.2147/IJN.S154555 Text en © 2018 Smilowitz et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Smilowitz, Henry M Meyers, Alexandria Rahman, Khalil Dyment, Nathaniel A Sasso, Dan Xue, Crystal Oliver, Douglas L Lichtler, Alexander Deng, Xiaomeng Ridwan, Sharif M Tarmu, Lauren J Wu, Qian Salner, Andrew L Bulsara, Ketan R Slatkin, Daniel N Hainfeld, James F Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title | Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title_full | Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title_fullStr | Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title_full_unstemmed | Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title_short | Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery |
title_sort | intravenously-injected gold nanoparticles (aunps) access intracerebral f98 rat gliomas better than aunps infused directly into the tumor site by convection enhanced delivery |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038872/ https://www.ncbi.nlm.nih.gov/pubmed/30013346 http://dx.doi.org/10.2147/IJN.S154555 |
work_keys_str_mv | AT smilowitzhenrym intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT meyersalexandria intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT rahmankhalil intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT dymentnathaniela intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT sassodan intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT xuecrystal intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT oliverdouglasl intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT lichtleralexander intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT dengxiaomeng intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT ridwansharifm intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT tarmulaurenj intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT wuqian intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT salnerandrewl intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT bulsaraketanr intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT slatkindanieln intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery AT hainfeldjamesf intravenouslyinjectedgoldnanoparticlesaunpsaccessintracerebralf98ratgliomasbetterthanaunpsinfuseddirectlyintothetumorsitebyconvectionenhanceddelivery |