Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery

BACKGROUND: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuN...

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Detalles Bibliográficos
Autores principales: Smilowitz, Henry M, Meyers, Alexandria, Rahman, Khalil, Dyment, Nathaniel A, Sasso, Dan, Xue, Crystal, Oliver, Douglas L, Lichtler, Alexander, Deng, Xiaomeng, Ridwan, Sharif M, Tarmu, Lauren J, Wu, Qian, Salner, Andrew L, Bulsara, Ketan R, Slatkin, Daniel N, Hainfeld, James F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038872/
https://www.ncbi.nlm.nih.gov/pubmed/30013346
http://dx.doi.org/10.2147/IJN.S154555

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