The role of histone lysine methyltransferase NSD3 in cancer

The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood....

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Detalles Bibliográficos
Autores principales: Han, Xu, Piao, Lianhua, Zhuang, Qianfeng, Yuan, Xiaofeng, Liu, Zhiwei, He, Xiaozhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038882/
https://www.ncbi.nlm.nih.gov/pubmed/30013365
http://dx.doi.org/10.2147/OTT.S166006
Descripción
Sumario:The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood. In this review, we summarize the current knowledge on the mechanisms underlying NSD3 regulation in different cancers. In addition, NSD3 may serve as a potential druggable target for selective cancer therapy in the future.

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