The role of histone lysine methyltransferase NSD3 in cancer

The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood....

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Detalles Bibliográficos
Autores principales: Han, Xu, Piao, Lianhua, Zhuang, Qianfeng, Yuan, Xiaofeng, Liu, Zhiwei, He, Xiaozhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038882/
https://www.ncbi.nlm.nih.gov/pubmed/30013365
http://dx.doi.org/10.2147/OTT.S166006
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author Han, Xu
Piao, Lianhua
Zhuang, Qianfeng
Yuan, Xiaofeng
Liu, Zhiwei
He, Xiaozhou
author_facet Han, Xu
Piao, Lianhua
Zhuang, Qianfeng
Yuan, Xiaofeng
Liu, Zhiwei
He, Xiaozhou
author_sort Han, Xu
collection PubMed
description The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood. In this review, we summarize the current knowledge on the mechanisms underlying NSD3 regulation in different cancers. In addition, NSD3 may serve as a potential druggable target for selective cancer therapy in the future.
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spelling pubmed-60388822018-07-16 The role of histone lysine methyltransferase NSD3 in cancer Han, Xu Piao, Lianhua Zhuang, Qianfeng Yuan, Xiaofeng Liu, Zhiwei He, Xiaozhou Onco Targets Ther Review The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood. In this review, we summarize the current knowledge on the mechanisms underlying NSD3 regulation in different cancers. In addition, NSD3 may serve as a potential druggable target for selective cancer therapy in the future. Dove Medical Press 2018-07-05 /pmc/articles/PMC6038882/ /pubmed/30013365 http://dx.doi.org/10.2147/OTT.S166006 Text en © 2018 Han et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Han, Xu
Piao, Lianhua
Zhuang, Qianfeng
Yuan, Xiaofeng
Liu, Zhiwei
He, Xiaozhou
The role of histone lysine methyltransferase NSD3 in cancer
title The role of histone lysine methyltransferase NSD3 in cancer
title_full The role of histone lysine methyltransferase NSD3 in cancer
title_fullStr The role of histone lysine methyltransferase NSD3 in cancer
title_full_unstemmed The role of histone lysine methyltransferase NSD3 in cancer
title_short The role of histone lysine methyltransferase NSD3 in cancer
title_sort role of histone lysine methyltransferase nsd3 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038882/
https://www.ncbi.nlm.nih.gov/pubmed/30013365
http://dx.doi.org/10.2147/OTT.S166006
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