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Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038987/ https://www.ncbi.nlm.nih.gov/pubmed/29990316 http://dx.doi.org/10.1371/journal.pone.0198121 |
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author | Georgescu, Emilian Oancea, Anca Georgescu, Florentina Nicolescu, Alina Oprita, Elena Iulia Vladulescu, Lucian Vladulescu, Marius-Constantin Oancea, Florin Shova, Sergiu Deleanu, Calin |
author_facet | Georgescu, Emilian Oancea, Anca Georgescu, Florentina Nicolescu, Alina Oprita, Elena Iulia Vladulescu, Lucian Vladulescu, Marius-Constantin Oancea, Florin Shova, Sergiu Deleanu, Calin |
author_sort | Georgescu, Emilian |
collection | PubMed |
description | Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues. |
format | Online Article Text |
id | pubmed-6038987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60389872018-07-19 Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues Georgescu, Emilian Oancea, Anca Georgescu, Florentina Nicolescu, Alina Oprita, Elena Iulia Vladulescu, Lucian Vladulescu, Marius-Constantin Oancea, Florin Shova, Sergiu Deleanu, Calin PLoS One Research Article Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues. Public Library of Science 2018-07-10 /pmc/articles/PMC6038987/ /pubmed/29990316 http://dx.doi.org/10.1371/journal.pone.0198121 Text en © 2018 Georgescu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Georgescu, Emilian Oancea, Anca Georgescu, Florentina Nicolescu, Alina Oprita, Elena Iulia Vladulescu, Lucian Vladulescu, Marius-Constantin Oancea, Florin Shova, Sergiu Deleanu, Calin Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title | Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title_full | Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title_fullStr | Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title_full_unstemmed | Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title_short | Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
title_sort | schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038987/ https://www.ncbi.nlm.nih.gov/pubmed/29990316 http://dx.doi.org/10.1371/journal.pone.0198121 |
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