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Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues

Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray...

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Autores principales: Georgescu, Emilian, Oancea, Anca, Georgescu, Florentina, Nicolescu, Alina, Oprita, Elena Iulia, Vladulescu, Lucian, Vladulescu, Marius-Constantin, Oancea, Florin, Shova, Sergiu, Deleanu, Calin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038987/
https://www.ncbi.nlm.nih.gov/pubmed/29990316
http://dx.doi.org/10.1371/journal.pone.0198121
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author Georgescu, Emilian
Oancea, Anca
Georgescu, Florentina
Nicolescu, Alina
Oprita, Elena Iulia
Vladulescu, Lucian
Vladulescu, Marius-Constantin
Oancea, Florin
Shova, Sergiu
Deleanu, Calin
author_facet Georgescu, Emilian
Oancea, Anca
Georgescu, Florentina
Nicolescu, Alina
Oprita, Elena Iulia
Vladulescu, Lucian
Vladulescu, Marius-Constantin
Oancea, Florin
Shova, Sergiu
Deleanu, Calin
author_sort Georgescu, Emilian
collection PubMed
description Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues.
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spelling pubmed-60389872018-07-19 Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues Georgescu, Emilian Oancea, Anca Georgescu, Florentina Nicolescu, Alina Oprita, Elena Iulia Vladulescu, Lucian Vladulescu, Marius-Constantin Oancea, Florin Shova, Sergiu Deleanu, Calin PLoS One Research Article Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues. Public Library of Science 2018-07-10 /pmc/articles/PMC6038987/ /pubmed/29990316 http://dx.doi.org/10.1371/journal.pone.0198121 Text en © 2018 Georgescu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Georgescu, Emilian
Oancea, Anca
Georgescu, Florentina
Nicolescu, Alina
Oprita, Elena Iulia
Vladulescu, Lucian
Vladulescu, Marius-Constantin
Oancea, Florin
Shova, Sergiu
Deleanu, Calin
Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title_full Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title_fullStr Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title_full_unstemmed Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title_short Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
title_sort schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038987/
https://www.ncbi.nlm.nih.gov/pubmed/29990316
http://dx.doi.org/10.1371/journal.pone.0198121
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