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Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors

High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signal...

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Autores principales: Alcántar-Fernández, Jonathan, Navarro, Rosa E., Salazar-Martínez, Ana María, Pérez-Andrade, Martha Elva, Miranda-Ríos, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039004/
https://www.ncbi.nlm.nih.gov/pubmed/29990370
http://dx.doi.org/10.1371/journal.pone.0199888
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author Alcántar-Fernández, Jonathan
Navarro, Rosa E.
Salazar-Martínez, Ana María
Pérez-Andrade, Martha Elva
Miranda-Ríos, Juan
author_facet Alcántar-Fernández, Jonathan
Navarro, Rosa E.
Salazar-Martínez, Ana María
Pérez-Andrade, Martha Elva
Miranda-Ríos, Juan
author_sort Alcántar-Fernández, Jonathan
collection PubMed
description High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed. In this study, we have determined that worms fed with high-glucose diets show alterations in glucose content and uptake, triglyceride content, body size, number of eggs laid, egg-laying defects, and signs of oxidative stress and accelerated aging. Additionally, we analyzed the participation of different key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity such as SKN-1/NRF2, HIF-1/HIF1α, SBP-1/SREBP, CRH-1/CREB, CEP-1/p53, and DAF-16/FOXO, in the reduction of lifespan in glucose-fed worms.
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spelling pubmed-60390042018-07-19 Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors Alcántar-Fernández, Jonathan Navarro, Rosa E. Salazar-Martínez, Ana María Pérez-Andrade, Martha Elva Miranda-Ríos, Juan PLoS One Research Article High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed. In this study, we have determined that worms fed with high-glucose diets show alterations in glucose content and uptake, triglyceride content, body size, number of eggs laid, egg-laying defects, and signs of oxidative stress and accelerated aging. Additionally, we analyzed the participation of different key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity such as SKN-1/NRF2, HIF-1/HIF1α, SBP-1/SREBP, CRH-1/CREB, CEP-1/p53, and DAF-16/FOXO, in the reduction of lifespan in glucose-fed worms. Public Library of Science 2018-07-10 /pmc/articles/PMC6039004/ /pubmed/29990370 http://dx.doi.org/10.1371/journal.pone.0199888 Text en © 2018 Alcántar-Fernández et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alcántar-Fernández, Jonathan
Navarro, Rosa E.
Salazar-Martínez, Ana María
Pérez-Andrade, Martha Elva
Miranda-Ríos, Juan
Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title_full Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title_fullStr Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title_full_unstemmed Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title_short Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
title_sort caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039004/
https://www.ncbi.nlm.nih.gov/pubmed/29990370
http://dx.doi.org/10.1371/journal.pone.0199888
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