Cargando…

Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density

During embryonic development bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes- the two main cell types within the liver. Cell fate decision depends on elaborate interactions between distinct signalling pathways, namely Notch, WNT, TGFβ, and Hedgehog. Several in vitro protoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Graffmann, Nina, Ncube, Audrey, Wruck, Wasco, Adjaye, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039024/ https://www.ncbi.nlm.nih.gov/pubmed/29990377 http://dx.doi.org/10.1371/journal.pone.0200416

Ejemplares similares

Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha
por: Graffmann, Nina, et al.
Publicado: (2016)

Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity
por: Wruck, Wasco, et al.
Publicado: (2021)

Editorial for Special Issue: iPS Cells (iPSCs) for Modelling and Treatment of Human Diseases
por: Graffmann, Nina, et al.
Publicado: (2022)

Correction: Nguyen et al. The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells. Cells 2022, 11, 635
por: Nguyen, Lisa, et al.
Publicado: (2022)

The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells
por: Nguyen, Lisa, et al.
Publicado: (2022)

Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines
por: Blessie, Ethel Juliet, et al.
Publicado: (2020)

A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference
por: Graffmann, Nina, et al.
Publicado: (2021)

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
por: Spitzhorn, Lucas-Sebastian, et al.
Publicado: (2019)

Human iPSC-derived iMSCs improve bone regeneration in mini-pigs
por: Jungbluth, Pascal, et al.
Publicado: (2019)

The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2(+) Urine Derived Renal Progenitor Cells
por: Rahman, Md Shaifur, et al.
Publicado: (2020)

The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time
por: Rahman, Md Shaifur, et al.
Publicado: (2018)

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants
por: Mlody, Barbara, et al.
Publicado: (2017)

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks
por: Matz, Peggy, et al.
Publicado: (2017)

Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis
por: Wruck, Wasco, et al.
Publicado: (2018)

Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease
por: Wruck, Wasco, et al.
Publicado: (2017)

Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain
por: Wruck, Wasco, et al.
Publicado: (2020)

SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress
por: Wruck, Wasco, et al.
Publicado: (2020)

Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa
por: Wruck, Wasco, et al.
Publicado: (2021)

Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome
por: Pranty, Abida Islam, et al.
Publicado: (2023)

Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models
por: Pranty, Abida Islam, et al.
Publicado: (2022)

miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells
por: Fuchs, Heiko, et al.
Publicado: (2014)

Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin
por: Royer-Pokora, Brigitte, et al.
Publicado: (2023)

Liver cell reprogramming: Parallels with iPSC biology
por: Yanger, Kilangsungla, et al.
Publicado: (2014)

Combined sequencing of mRNA and DNA from human embryonic stem cells
por: Mertes, Florian, et al.
Publicado: (2016)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients
por: Karikari, Akua A., et al.
Publicado: (2021)

FGF signal is not required for hepatoblast differentiation of human iPS cells
por: Toba, Yukiko, et al.
Publicado: (2019)

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
por: Jamieson, John J., et al.
Publicado: (2019)

iPSC-Based Cell Therapy: An Important Step Forward
por: Rao, Mahendra
Publicado: (2013)

Cells derived from iPSC can be immunogenic — Yes or No?
por: Cao, Jiani, et al.
Publicado: (2014)

Robust detection of undifferentiated iPSC among differentiated cells
por: Sekine, Keisuke, et al.
Publicado: (2020)

Modeling Alzheimer’s disease with iPSC-derived brain cells
por: Penney, Jay, et al.
Publicado: (2019)

iPSC-Derived Natural Killer Cells for Cancer Immunotherapy
por: Karagiannis, Peter, et al.
Publicado: (2021)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Human iPSC-derived glia models for the study of neuroinflammation
por: Stöberl, Nina, et al.
Publicado: (2023)

Natural Products in Renal-Associated Drug Discovery
por: Wruck, Wasco, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_40rvkhaqpmskn48kiet6l3scmo