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Orbital frontal cortex updates state-induced value change for decision-making

Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC’s contribution to goal-directed or model-based behavior, where the decision to act is controlled by previous experience with the consequence or outcome....

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Autores principales: Baltz, Emily T, Yalcinbas, Ege A, Renteria, Rafael, Gremel, Christina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039177/
https://www.ncbi.nlm.nih.gov/pubmed/29897332
http://dx.doi.org/10.7554/eLife.35988
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author Baltz, Emily T
Yalcinbas, Ege A
Renteria, Rafael
Gremel, Christina M
author_facet Baltz, Emily T
Yalcinbas, Ege A
Renteria, Rafael
Gremel, Christina M
author_sort Baltz, Emily T
collection PubMed
description Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC’s contribution to goal-directed or model-based behavior, where the decision to act is controlled by previous experience with the consequence or outcome. Investigating OFC’s role in learning about changed outcomes separate from decision-making is not trivial and often the two are confounded. Here we adapted an incentive learning task to mice, where we investigated processes controlling experience-based outcome updating independent from inferred action control. We found chemogenetic OFC attenuation did not alter the ability to perceive motivational state-induced changes in outcome value but did prevent the experience-based updating of this change. Optogenetic inhibition of OFC excitatory neuron activity selectively when experiencing an outcome change disrupted the ability to update, leaving mice unable to infer the appropriate behavior. Our findings support a role for OFC in learning that controls decision-making.
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spelling pubmed-60391772018-07-11 Orbital frontal cortex updates state-induced value change for decision-making Baltz, Emily T Yalcinbas, Ege A Renteria, Rafael Gremel, Christina M eLife Neuroscience Recent hypotheses have posited that orbital frontal cortex (OFC) is important for using inferred consequences to guide behavior. Less clear is OFC’s contribution to goal-directed or model-based behavior, where the decision to act is controlled by previous experience with the consequence or outcome. Investigating OFC’s role in learning about changed outcomes separate from decision-making is not trivial and often the two are confounded. Here we adapted an incentive learning task to mice, where we investigated processes controlling experience-based outcome updating independent from inferred action control. We found chemogenetic OFC attenuation did not alter the ability to perceive motivational state-induced changes in outcome value but did prevent the experience-based updating of this change. Optogenetic inhibition of OFC excitatory neuron activity selectively when experiencing an outcome change disrupted the ability to update, leaving mice unable to infer the appropriate behavior. Our findings support a role for OFC in learning that controls decision-making. eLife Sciences Publications, Ltd 2018-06-13 /pmc/articles/PMC6039177/ /pubmed/29897332 http://dx.doi.org/10.7554/eLife.35988 Text en © 2018, Baltz et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Baltz, Emily T
Yalcinbas, Ege A
Renteria, Rafael
Gremel, Christina M
Orbital frontal cortex updates state-induced value change for decision-making
title Orbital frontal cortex updates state-induced value change for decision-making
title_full Orbital frontal cortex updates state-induced value change for decision-making
title_fullStr Orbital frontal cortex updates state-induced value change for decision-making
title_full_unstemmed Orbital frontal cortex updates state-induced value change for decision-making
title_short Orbital frontal cortex updates state-induced value change for decision-making
title_sort orbital frontal cortex updates state-induced value change for decision-making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039177/
https://www.ncbi.nlm.nih.gov/pubmed/29897332
http://dx.doi.org/10.7554/eLife.35988
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