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The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease

A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixodes scapularis, which transmits multiple pathogens including the agents of Lyme disease and human granulocytic anaplasmosis. When mRNA encoding IscaGluCl1 was expressed in Xenopus laevis oocytes, we d...

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Detalles Bibliográficos
Autores principales:	Furutani, Shogo, Ihara, Makoto, Lees, Kristin, Buckingham, Steven D., Partridge, Frederick A., David, Jonathan A., Patel, Rohit, Warchal, Scott, Mellor, Ian R., Matsuda, Kazuhiko, Sattelle, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039357/ https://www.ncbi.nlm.nih.gov/pubmed/29957333 http://dx.doi.org/10.1016/j.ijpddr.2018.06.001

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