A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder. Despite its severity, there are no effective treatments because of the complexity of its pathogenesis. As one of the underlying mechanisms of Cu, Zn superoxide dismutase (SOD1) gene mutation-induced ALS, SOD1 mutants (S...

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Detalles Bibliográficos
Autores principales: Tsuburaya, Naomi, Homma, Kengo, Higuchi, Tsunehiko, Balia, Andrii, Yamakoshi, Hiroyuki, Shibata, Norio, Nakamura, Seiichi, Nakagawa, Hidehiko, Ikeda, Shin-ichi, Umezawa, Naoki, Kato, Nobuki, Yokoshima, Satoshi, Shibuya, Masatoshi, Shimonishi, Manabu, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Naguro, Isao, Imamura, Keiko, Inoue, Haruhisa, Fujisawa, Takao, Ichijo, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039432/
https://www.ncbi.nlm.nih.gov/pubmed/29991716
http://dx.doi.org/10.1038/s41467-018-05127-2

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