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Structural insights into ubiquitin phosphorylation by PINK1

Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. These two proteins are essential for ubiquitylation of damaged mitochondria and subsequent degradation. PINK1 phosphorylates Ser65 of Ub and the Ub-like (UBL) domain of parkin...

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Detalles Bibliográficos
Autores principales:	Okatsu, Kei, Sato, Yusuke, Yamano, Koji, Matsuda, Noriyuki, Negishi, Lumi, Takahashi, Akiko, Yamagata, Atsushi, Goto-Ito, Sakurako, Mishima, Masaki, Ito, Yutaka, Oka, Toshihiko, Tanaka, Keiji, Fukai, Shuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039469/ https://www.ncbi.nlm.nih.gov/pubmed/29991771 http://dx.doi.org/10.1038/s41598-018-28656-8

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