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A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

Sirtuin-1 (SIRT1), the mammalian ortholog of yeast Sir2p, is well known to be a highly conserved NAD(+)-dependent protein deacetylase that has been emerging as a key cancer target. Autophagy, an evolutionarily conserved, multi-step lysosomal degradation process, has been implicated in cancer. Accumu...

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Detalles Bibliográficos
Autores principales:	Yao, Zhi-qiang, Zhang, Xin, Zhen, Yongqi, He, Xu-Ying, Zhao, Shuangmei, Li, Xi-Feng, Yang, Bo, Gao, Feng, Guo, Fu-You, Fu, Leilei, Liu, Xian-Zhi, Duan, Chuan-Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039470/ https://www.ncbi.nlm.nih.gov/pubmed/29991742 http://dx.doi.org/10.1038/s41419-018-0799-z

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