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Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease

Recent improvements in neuroimaging and molecular markers of Alzheimer’s disease (AD) have aided diagnosis in the early stage of the disease, which greatly increases the chance for successful prevention and treatment. However, the expanding resources for AD diagnosis are unlikely to benefit all elde...

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Autores principales: Kim, Ko Woon, Choi, Jong Doo, Lee, Hyejoo, Lee, Na Kyung, Park, Seongbeom, Chin, Juhee, Lee, Byung Hwa, Shin, Jiwon, Kim, Yeshin, Jang, Hyemin, Choi, Jee Hyun, Na, Duk L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039498/
https://www.ncbi.nlm.nih.gov/pubmed/29991732
http://dx.doi.org/10.1038/s41598-018-28768-1
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author Kim, Ko Woon
Choi, Jong Doo
Lee, Hyejoo
Lee, Na Kyung
Park, Seongbeom
Chin, Juhee
Lee, Byung Hwa
Shin, Jiwon
Kim, Yeshin
Jang, Hyemin
Choi, Jee Hyun
Na, Duk L.
author_facet Kim, Ko Woon
Choi, Jong Doo
Lee, Hyejoo
Lee, Na Kyung
Park, Seongbeom
Chin, Juhee
Lee, Byung Hwa
Shin, Jiwon
Kim, Yeshin
Jang, Hyemin
Choi, Jee Hyun
Na, Duk L.
author_sort Kim, Ko Woon
collection PubMed
description Recent improvements in neuroimaging and molecular markers of Alzheimer’s disease (AD) have aided diagnosis in the early stage of the disease, which greatly increases the chance for successful prevention and treatment. However, the expanding resources for AD diagnosis are unlikely to benefit all elderly due to economic burden. Here, we aimed to develop an inexpensive and sensitive method to detect early-stage AD. A scenario for real-world social event memory test (SEMT) was created and filmed in 360° video. Participants watched the 7-min video through head-mounted display (HMD) and then answered questionnaire about the video. We categorized the SEMT score into recall, recognition, and place-matching scores and compared them to scores on the Mini-Mental State Examination and Seoul Verbal Learning Test. Using the SEMT scores, we built a logistic regression model that discriminated between amyloid positivity and negativity of the participants, with a cross-validation AUC. Furthermore, a classifier was created using support vector machine, which produced 93.8–95.1% sensitivity in classifying individuals into four groups of normal, mild cognitive impairment with or without amyloid, and AD elderly. The high correlation between the SEMT score and amyloid positivity in individuals who experienced virtual social gathering through an HMD opens a new possibility for early diagnosis of AD.
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spelling pubmed-60394982018-07-12 Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease Kim, Ko Woon Choi, Jong Doo Lee, Hyejoo Lee, Na Kyung Park, Seongbeom Chin, Juhee Lee, Byung Hwa Shin, Jiwon Kim, Yeshin Jang, Hyemin Choi, Jee Hyun Na, Duk L. Sci Rep Article Recent improvements in neuroimaging and molecular markers of Alzheimer’s disease (AD) have aided diagnosis in the early stage of the disease, which greatly increases the chance for successful prevention and treatment. However, the expanding resources for AD diagnosis are unlikely to benefit all elderly due to economic burden. Here, we aimed to develop an inexpensive and sensitive method to detect early-stage AD. A scenario for real-world social event memory test (SEMT) was created and filmed in 360° video. Participants watched the 7-min video through head-mounted display (HMD) and then answered questionnaire about the video. We categorized the SEMT score into recall, recognition, and place-matching scores and compared them to scores on the Mini-Mental State Examination and Seoul Verbal Learning Test. Using the SEMT scores, we built a logistic regression model that discriminated between amyloid positivity and negativity of the participants, with a cross-validation AUC. Furthermore, a classifier was created using support vector machine, which produced 93.8–95.1% sensitivity in classifying individuals into four groups of normal, mild cognitive impairment with or without amyloid, and AD elderly. The high correlation between the SEMT score and amyloid positivity in individuals who experienced virtual social gathering through an HMD opens a new possibility for early diagnosis of AD. Nature Publishing Group UK 2018-07-10 /pmc/articles/PMC6039498/ /pubmed/29991732 http://dx.doi.org/10.1038/s41598-018-28768-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Ko Woon
Choi, Jong Doo
Lee, Hyejoo
Lee, Na Kyung
Park, Seongbeom
Chin, Juhee
Lee, Byung Hwa
Shin, Jiwon
Kim, Yeshin
Jang, Hyemin
Choi, Jee Hyun
Na, Duk L.
Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title_full Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title_fullStr Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title_full_unstemmed Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title_short Social Event Memory Test (SEMT): A Video-based Memory Test for Predicting Amyloid Positivity for Alzheimer’s Disease
title_sort social event memory test (semt): a video-based memory test for predicting amyloid positivity for alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039498/
https://www.ncbi.nlm.nih.gov/pubmed/29991732
http://dx.doi.org/10.1038/s41598-018-28768-1
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