Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy

The 8(th) edition of TNM staging system has been released and it incorporates many changes to the T and N classifications for pancreatic cancer. Comparative study between the 7(th) and 8(th) edition of TNM staging system from Asian population has not been reported yet. This study aimed to compare th...

Descripción completa

Detalles Bibliográficos
Autores principales: Cong, Lin, Liu, Qiaofei, Zhang, Ronghua, Cui, Ming, Zhang, Xiang, Gao, Xiang, Guo, Junchao, Dai, Menghua, Zhang, Taiping, Liao, Quan, Zhao, Yupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039534/
https://www.ncbi.nlm.nih.gov/pubmed/29991730
http://dx.doi.org/10.1038/s41598-018-28193-4
_version_ 1783338692107042816
author Cong, Lin
Liu, Qiaofei
Zhang, Ronghua
Cui, Ming
Zhang, Xiang
Gao, Xiang
Guo, Junchao
Dai, Menghua
Zhang, Taiping
Liao, Quan
Zhao, Yupei
author_facet Cong, Lin
Liu, Qiaofei
Zhang, Ronghua
Cui, Ming
Zhang, Xiang
Gao, Xiang
Guo, Junchao
Dai, Menghua
Zhang, Taiping
Liao, Quan
Zhao, Yupei
author_sort Cong, Lin
collection PubMed
description The 8(th) edition of TNM staging system has been released and it incorporates many changes to the T and N classifications for pancreatic cancer. Comparative study between the 7(th) and 8(th) edition of TNM staging system from Asian population has not been reported yet. This study aimed to compare the 7(th) and 8(th) edition of staging system for pancreatic cancer by using a cohort of pancreatic cancer patients from China after R0 pancreaticoduodenectomy and adjuvant chemotherapy. The results showed according to the pT classification of 7(th) edition, pT3 was predominant (87.25%), however, the new edition led to a more equal distribution of pT classification. pT1, pT2 and pT3 was 27.45%, 56.86% and 15.69%, respectively. According to the new pN classification, 18.63% of the patients were pN2. The pT classification in the 8(th) edition was significantly superior to that in the 7(th) edition at stratifying patients by overall survival. The pN classification in the 8(th) edition failed to show an advantage over the 7(th) edition in stratifying patients by overall survival. Therefore, the new pT classification, but not the new pN classification, showed a significant advantage over the previous edition at predicting the overall survival of pancreatic cancer patients.
format Online
Article
Text
id pubmed-6039534
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-60395342018-07-12 Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy Cong, Lin Liu, Qiaofei Zhang, Ronghua Cui, Ming Zhang, Xiang Gao, Xiang Guo, Junchao Dai, Menghua Zhang, Taiping Liao, Quan Zhao, Yupei Sci Rep Article The 8(th) edition of TNM staging system has been released and it incorporates many changes to the T and N classifications for pancreatic cancer. Comparative study between the 7(th) and 8(th) edition of TNM staging system from Asian population has not been reported yet. This study aimed to compare the 7(th) and 8(th) edition of staging system for pancreatic cancer by using a cohort of pancreatic cancer patients from China after R0 pancreaticoduodenectomy and adjuvant chemotherapy. The results showed according to the pT classification of 7(th) edition, pT3 was predominant (87.25%), however, the new edition led to a more equal distribution of pT classification. pT1, pT2 and pT3 was 27.45%, 56.86% and 15.69%, respectively. According to the new pN classification, 18.63% of the patients were pN2. The pT classification in the 8(th) edition was significantly superior to that in the 7(th) edition at stratifying patients by overall survival. The pN classification in the 8(th) edition failed to show an advantage over the 7(th) edition in stratifying patients by overall survival. Therefore, the new pT classification, but not the new pN classification, showed a significant advantage over the previous edition at predicting the overall survival of pancreatic cancer patients. Nature Publishing Group UK 2018-07-10 /pmc/articles/PMC6039534/ /pubmed/29991730 http://dx.doi.org/10.1038/s41598-018-28193-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cong, Lin
Liu, Qiaofei
Zhang, Ronghua
Cui, Ming
Zhang, Xiang
Gao, Xiang
Guo, Junchao
Dai, Menghua
Zhang, Taiping
Liao, Quan
Zhao, Yupei
Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title_full Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title_fullStr Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title_full_unstemmed Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title_short Tumor size classification of the 8(th) edition of TNM staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
title_sort tumor size classification of the 8(th) edition of tnm staging system is superior to that of the 7(th) edition in predicting the survival outcome of pancreatic cancer patients after radical resection and adjuvant chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039534/
https://www.ncbi.nlm.nih.gov/pubmed/29991730
http://dx.doi.org/10.1038/s41598-018-28193-4
work_keys_str_mv AT conglin tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT liuqiaofei tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT zhangronghua tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT cuiming tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT zhangxiang tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT gaoxiang tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT guojunchao tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT daimenghua tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT zhangtaiping tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT liaoquan tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy
AT zhaoyupei tumorsizeclassificationofthe8theditionoftnmstagingsystemissuperiortothatofthe7theditioninpredictingthesurvivaloutcomeofpancreaticcancerpatientsafterradicalresectionandadjuvantchemotherapy

Ejemplares similares