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Seamless phase IIa/IIb adaptive design with the same primary endpoint for proof of concept and dose finding

This paper considers combining a proof of concept (POC) study and a dose finding (DF) study where the POC and the DF share the same primary endpoint. An example based on real study conditions shows that compared to a conventional design the proposed adaptive design tests more active doses, with a sm...

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Detalles Bibliográficos
Autores principales:	Yuan, Jiacheng, Radecki, Daniel, Bugarin, Denise, Geib, Till, Zhou, Jihao, Liu, Jeen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039539/ https://www.ncbi.nlm.nih.gov/pubmed/30003170 http://dx.doi.org/10.1016/j.conctc.2018.06.006

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