Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

Components of the Fanconi anemia and homologous recombination pathways play a vital role in protecting newly replicated DNA from uncontrolled nucleolytic degradation, safeguarding genome stability. Here we report that histone methylation by the lysine methyltransferase SETD1A is crucial for protecti...

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Detalles Bibliográficos
Autores principales: Higgs, Martin R., Sato, Koichi, Reynolds, John J., Begum, Shabana, Bayley, Rachel, Goula, Amalia, Vernet, Audrey, Paquin, Karissa L., Skalnik, David G., Kobayashi, Wataru, Takata, Minoru, Howlett, Niall G., Kurumizaka, Hitoshi, Kimura, Hiroshi, Stewart, Grant S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039718/
https://www.ncbi.nlm.nih.gov/pubmed/29937342
http://dx.doi.org/10.1016/j.molcel.2018.05.018

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