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It takes two to pantomime: Communication meets motor cognition

For over a century, pantomime of tool use has been employed to diagnose limb apraxia, a disorder of motor cognition primarily induced by left brain damage. While research consistently implicates damage to a left fronto-temporo-parietal network in limb apraxia, findings are inconsistent regarding the...

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Autores principales: Finkel, Lisa, Hogrefe, Katharina, Frey, Scott H., Goldenberg, Georg, Randerath, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039835/
https://www.ncbi.nlm.nih.gov/pubmed/30003038
http://dx.doi.org/10.1016/j.nicl.2018.06.019
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author Finkel, Lisa
Hogrefe, Katharina
Frey, Scott H.
Goldenberg, Georg
Randerath, Jennifer
author_facet Finkel, Lisa
Hogrefe, Katharina
Frey, Scott H.
Goldenberg, Georg
Randerath, Jennifer
author_sort Finkel, Lisa
collection PubMed
description For over a century, pantomime of tool use has been employed to diagnose limb apraxia, a disorder of motor cognition primarily induced by left brain damage. While research consistently implicates damage to a left fronto-temporo-parietal network in limb apraxia, findings are inconsistent regarding the impact of damage to anterior versus posterior nodes within this network on pantomime. Complicating matters is the fact that tool use pantomime can be affected and evaluated at multiple levels. For instance, the production of tool use gestures requires the consideration of semantic characteristics (e.g. how to communicate the action intention) as well as motor features (e.g. forming grip and movement). Together, these factors may contribute substantially to apparent discrepancies in previously reported findings regarding neural correlates of tool use pantomime. In the current study, 67 stroke patients with unilateral left-brain damage performed a classic pantomime task. In order to analyze different error characteristics, we evaluated the proper use of grip and movement for each pantomime. For certain objects, healthy subjects may use body parts as representative for the object, e.g. use of the fingers to indicate scissors blades. To specify the pathological use of body parts as the object (BPO) we only assessed pantomime items that were not prone to this response in healthy participants. We performed modern voxel-based lesion analyses on MRI or CT data to determine associations between brain injury and the frequency of the specific types of pantomime errors. Our results support a model in which anterior and posterior nodes of the left fronto-temporo-parietal network contribute differentially to pantomime of tool use. More precisely, damage in the inferior frontal cortex reaching to the temporal pole is associated with an increased frequency of BPO errors, whereas damage to the inferior parietal lobe is predominantly linked to an increased frequency of movement and/or grip errors. Our work suggests that the validity of attempts to specify the neural correlates of limb apraxia based on tool use pantomime depends on differentiating the specific types of errors committed. We conclude that successful tool use pantomime involves dissociable functions with communicative aspects represented in more anterior (rather ventral) regions and motor-cognitive aspects in more posterior (rather dorsal) nodes of a left fronto-temporo-parietal network.
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spelling pubmed-60398352018-07-12 It takes two to pantomime: Communication meets motor cognition Finkel, Lisa Hogrefe, Katharina Frey, Scott H. Goldenberg, Georg Randerath, Jennifer Neuroimage Clin Regular Article For over a century, pantomime of tool use has been employed to diagnose limb apraxia, a disorder of motor cognition primarily induced by left brain damage. While research consistently implicates damage to a left fronto-temporo-parietal network in limb apraxia, findings are inconsistent regarding the impact of damage to anterior versus posterior nodes within this network on pantomime. Complicating matters is the fact that tool use pantomime can be affected and evaluated at multiple levels. For instance, the production of tool use gestures requires the consideration of semantic characteristics (e.g. how to communicate the action intention) as well as motor features (e.g. forming grip and movement). Together, these factors may contribute substantially to apparent discrepancies in previously reported findings regarding neural correlates of tool use pantomime. In the current study, 67 stroke patients with unilateral left-brain damage performed a classic pantomime task. In order to analyze different error characteristics, we evaluated the proper use of grip and movement for each pantomime. For certain objects, healthy subjects may use body parts as representative for the object, e.g. use of the fingers to indicate scissors blades. To specify the pathological use of body parts as the object (BPO) we only assessed pantomime items that were not prone to this response in healthy participants. We performed modern voxel-based lesion analyses on MRI or CT data to determine associations between brain injury and the frequency of the specific types of pantomime errors. Our results support a model in which anterior and posterior nodes of the left fronto-temporo-parietal network contribute differentially to pantomime of tool use. More precisely, damage in the inferior frontal cortex reaching to the temporal pole is associated with an increased frequency of BPO errors, whereas damage to the inferior parietal lobe is predominantly linked to an increased frequency of movement and/or grip errors. Our work suggests that the validity of attempts to specify the neural correlates of limb apraxia based on tool use pantomime depends on differentiating the specific types of errors committed. We conclude that successful tool use pantomime involves dissociable functions with communicative aspects represented in more anterior (rather ventral) regions and motor-cognitive aspects in more posterior (rather dorsal) nodes of a left fronto-temporo-parietal network. Elsevier 2018-06-21 /pmc/articles/PMC6039835/ /pubmed/30003038 http://dx.doi.org/10.1016/j.nicl.2018.06.019 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Finkel, Lisa
Hogrefe, Katharina
Frey, Scott H.
Goldenberg, Georg
Randerath, Jennifer
It takes two to pantomime: Communication meets motor cognition
title It takes two to pantomime: Communication meets motor cognition
title_full It takes two to pantomime: Communication meets motor cognition
title_fullStr It takes two to pantomime: Communication meets motor cognition
title_full_unstemmed It takes two to pantomime: Communication meets motor cognition
title_short It takes two to pantomime: Communication meets motor cognition
title_sort it takes two to pantomime: communication meets motor cognition
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039835/
https://www.ncbi.nlm.nih.gov/pubmed/30003038
http://dx.doi.org/10.1016/j.nicl.2018.06.019
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