Cargando…

Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET

Visually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign, is a feature of dementia with Lewy bodies (DLB) on FDG-PET. Lower cingulate island sign ratio (posterior cingulate cortex/cuneus+precuneus; FDG-CISr) values have...

Descripción completa

Detalles Bibliográficos
Autores principales: Nedelska, Zuzana, Senjem, Matthew L., Przybelski, Scott A., Lesnick, Timothy G., Lowe, Val J., Boeve, Bradley F., Arani, Arvin, Vemuri, Prashanthi, Graff-Radford, Jonathan, Ferman, Tanis J., Jones, David T., Savica, Rodolfo, Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Kantarci, Kejal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039836/
https://www.ncbi.nlm.nih.gov/pubmed/30003031
http://dx.doi.org/10.1016/j.nicl.2018.06.020
_version_ 1783338750879727616
author Nedelska, Zuzana
Senjem, Matthew L.
Przybelski, Scott A.
Lesnick, Timothy G.
Lowe, Val J.
Boeve, Bradley F.
Arani, Arvin
Vemuri, Prashanthi
Graff-Radford, Jonathan
Ferman, Tanis J.
Jones, David T.
Savica, Rodolfo
Knopman, David S.
Petersen, Ronald C.
Jack, Clifford R.
Kantarci, Kejal
author_facet Nedelska, Zuzana
Senjem, Matthew L.
Przybelski, Scott A.
Lesnick, Timothy G.
Lowe, Val J.
Boeve, Bradley F.
Arani, Arvin
Vemuri, Prashanthi
Graff-Radford, Jonathan
Ferman, Tanis J.
Jones, David T.
Savica, Rodolfo
Knopman, David S.
Petersen, Ronald C.
Jack, Clifford R.
Kantarci, Kejal
author_sort Nedelska, Zuzana
collection PubMed
description Visually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign, is a feature of dementia with Lewy bodies (DLB) on FDG-PET. Lower cingulate island sign ratio (posterior cingulate cortex/cuneus+precuneus; FDG-CISr) values have been associated with a higher Braak neurofibrillary tangle stage in autopsied DLB. Using voxel-wise analysis, we assessed the patterns of regional cortical perfusion and metabolism, and using an atlas-based approach, we measured perfusion cingulate island sign ratio on arterial spin labeling MRI (ASL-CISr), and its associations with FDG-CISr, uptake on tau-PET and clinical severity in DLB. Our study sample (n = 114) included clinically probable DLB patients (n = 19), age-matched patients with probable Alzheimer's disease dementia (AD; n = 19) and matched controls (n = 76) who underwent MRI with 3-dimensional pseudo-continuous arterial spin labeling, 18F-FDG-PET and 18F-AV-1451 tau PET. Patterns of cortical perfusion and metabolism were derived from quantitative maps using Statistical Parametric Mapping. DLB patients showed hypoperfusion on ASL-MRI in precuneus, cuneus and posterior parieto-occipital cortices, compared to controls, and relatively spared posterior cingulate gyrus, similar to pattern of hypometabolism on FDG-PET. DLB patients had higher ASL-CISr and FDG-CISr than AD patients (p <0.001). ASL-CISr correlated with FDG-CISr in DLB patients (r = 0.67; p =0.002). Accuracy of distinguishing DLB from AD patients was 0.80 for ASL-CISr and 0.91 for FDG-CISr. Lower ASL-CISr was moderately associated with a higher composite medial temporal AV-1451 uptake (r = −0.50; p =0.03) in DLB. Lower perfusion in precuneus and cuneus was associated with worse global clinical scores. In summary, the pattern of cortical hypoperfusion on ASL-MRI is similar to hypometabolism on FDG-PET, and respective cingulate island sign ratios correlate with each other in DLB. Non-invasive and radiotracer-free ASL-MRI may be further developed as a tool for the screening and diagnostic evaluation of DLB patients in a variety of clinical settings where FDG-PET is not accessible.
format Online
Article
Text
id pubmed-6039836
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-60398362018-07-12 Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET Nedelska, Zuzana Senjem, Matthew L. Przybelski, Scott A. Lesnick, Timothy G. Lowe, Val J. Boeve, Bradley F. Arani, Arvin Vemuri, Prashanthi Graff-Radford, Jonathan Ferman, Tanis J. Jones, David T. Savica, Rodolfo Knopman, David S. Petersen, Ronald C. Jack, Clifford R. Kantarci, Kejal Neuroimage Clin Regular Article Visually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign, is a feature of dementia with Lewy bodies (DLB) on FDG-PET. Lower cingulate island sign ratio (posterior cingulate cortex/cuneus+precuneus; FDG-CISr) values have been associated with a higher Braak neurofibrillary tangle stage in autopsied DLB. Using voxel-wise analysis, we assessed the patterns of regional cortical perfusion and metabolism, and using an atlas-based approach, we measured perfusion cingulate island sign ratio on arterial spin labeling MRI (ASL-CISr), and its associations with FDG-CISr, uptake on tau-PET and clinical severity in DLB. Our study sample (n = 114) included clinically probable DLB patients (n = 19), age-matched patients with probable Alzheimer's disease dementia (AD; n = 19) and matched controls (n = 76) who underwent MRI with 3-dimensional pseudo-continuous arterial spin labeling, 18F-FDG-PET and 18F-AV-1451 tau PET. Patterns of cortical perfusion and metabolism were derived from quantitative maps using Statistical Parametric Mapping. DLB patients showed hypoperfusion on ASL-MRI in precuneus, cuneus and posterior parieto-occipital cortices, compared to controls, and relatively spared posterior cingulate gyrus, similar to pattern of hypometabolism on FDG-PET. DLB patients had higher ASL-CISr and FDG-CISr than AD patients (p <0.001). ASL-CISr correlated with FDG-CISr in DLB patients (r = 0.67; p =0.002). Accuracy of distinguishing DLB from AD patients was 0.80 for ASL-CISr and 0.91 for FDG-CISr. Lower ASL-CISr was moderately associated with a higher composite medial temporal AV-1451 uptake (r = −0.50; p =0.03) in DLB. Lower perfusion in precuneus and cuneus was associated with worse global clinical scores. In summary, the pattern of cortical hypoperfusion on ASL-MRI is similar to hypometabolism on FDG-PET, and respective cingulate island sign ratios correlate with each other in DLB. Non-invasive and radiotracer-free ASL-MRI may be further developed as a tool for the screening and diagnostic evaluation of DLB patients in a variety of clinical settings where FDG-PET is not accessible. Elsevier 2018-06-19 /pmc/articles/PMC6039836/ /pubmed/30003031 http://dx.doi.org/10.1016/j.nicl.2018.06.020 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Nedelska, Zuzana
Senjem, Matthew L.
Przybelski, Scott A.
Lesnick, Timothy G.
Lowe, Val J.
Boeve, Bradley F.
Arani, Arvin
Vemuri, Prashanthi
Graff-Radford, Jonathan
Ferman, Tanis J.
Jones, David T.
Savica, Rodolfo
Knopman, David S.
Petersen, Ronald C.
Jack, Clifford R.
Kantarci, Kejal
Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title_full Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title_fullStr Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title_full_unstemmed Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title_short Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET
title_sort regional cortical perfusion on arterial spin labeling mri in dementia with lewy bodies: associations with clinical severity, glucose metabolism and tau pet
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039836/
https://www.ncbi.nlm.nih.gov/pubmed/30003031
http://dx.doi.org/10.1016/j.nicl.2018.06.020
work_keys_str_mv AT nedelskazuzana regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT senjemmatthewl regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT przybelskiscotta regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT lesnicktimothyg regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT lowevalj regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT boevebradleyf regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT araniarvin regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT vemuriprashanthi regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT graffradfordjonathan regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT fermantanisj regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT jonesdavidt regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT savicarodolfo regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT knopmandavids regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT petersenronaldc regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT jackcliffordr regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet
AT kantarcikejal regionalcorticalperfusiononarterialspinlabelingmriindementiawithlewybodiesassociationswithclinicalseverityglucosemetabolismandtaupet