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Brain activation during the expectations of sensory experience for cutaneous electrical stimulation

The brain actively interprets sensory inputs by integrating top-down and bottom-up information. Humans can make inferences on somatosensation based on prior experiences and expectations even without the actual stimulation. We used functional magnetic resonance imaging to investigate the neural subst...

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Autores principales: Jung, Won-Mo, Ryu, Yeonhee, Park, Hi-Joon, Lee, Hyejung, Chae, Younbyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039842/
https://www.ncbi.nlm.nih.gov/pubmed/30003035
http://dx.doi.org/10.1016/j.nicl.2018.06.022
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author Jung, Won-Mo
Ryu, Yeonhee
Park, Hi-Joon
Lee, Hyejung
Chae, Younbyoung
author_facet Jung, Won-Mo
Ryu, Yeonhee
Park, Hi-Joon
Lee, Hyejung
Chae, Younbyoung
author_sort Jung, Won-Mo
collection PubMed
description The brain actively interprets sensory inputs by integrating top-down and bottom-up information. Humans can make inferences on somatosensation based on prior experiences and expectations even without the actual stimulation. We used functional magnetic resonance imaging to investigate the neural substrates of the expectations of the sensory experience of cutaneous electrical stimulation on acupoint without actual stimuli. This study included 22 participants who wore sticker-type electrodes attached on three different acupoints on different body regions: CV17 (chest), CV23 (chin), and left PC6 (arm). Participants evaluated de qi sensations after they expected electrical stimulation on those points in random order without actual stimulation. All stimuli were presented with corresponding visual information of the stimulation sites. The control condition included the same visual information but outside the body. The expectations of cutaneous electrical stimuli without actual stimulation on three acupoints resulted in greater de qi sensation compared to the control condition. Cognitive components of cutaneous electrical stimulation exhibited greater brain activation in the anterior insula, pre-supplementary motor area, and secondary somatosensory area. The expectations of acupuncture stimulation exhibited a distinct experience of somatosensation as well as brain activations in insula and pre-supplementary motor area. Our findings suggest that the sensory experience of the pseudo-cutaneous stimulation may be derived from the predictive role of the salience network in monitoring internal and external body states.
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spelling pubmed-60398422018-07-12 Brain activation during the expectations of sensory experience for cutaneous electrical stimulation Jung, Won-Mo Ryu, Yeonhee Park, Hi-Joon Lee, Hyejung Chae, Younbyoung Neuroimage Clin Regular Article The brain actively interprets sensory inputs by integrating top-down and bottom-up information. Humans can make inferences on somatosensation based on prior experiences and expectations even without the actual stimulation. We used functional magnetic resonance imaging to investigate the neural substrates of the expectations of the sensory experience of cutaneous electrical stimulation on acupoint without actual stimuli. This study included 22 participants who wore sticker-type electrodes attached on three different acupoints on different body regions: CV17 (chest), CV23 (chin), and left PC6 (arm). Participants evaluated de qi sensations after they expected electrical stimulation on those points in random order without actual stimulation. All stimuli were presented with corresponding visual information of the stimulation sites. The control condition included the same visual information but outside the body. The expectations of cutaneous electrical stimuli without actual stimulation on three acupoints resulted in greater de qi sensation compared to the control condition. Cognitive components of cutaneous electrical stimulation exhibited greater brain activation in the anterior insula, pre-supplementary motor area, and secondary somatosensory area. The expectations of acupuncture stimulation exhibited a distinct experience of somatosensation as well as brain activations in insula and pre-supplementary motor area. Our findings suggest that the sensory experience of the pseudo-cutaneous stimulation may be derived from the predictive role of the salience network in monitoring internal and external body states. Elsevier 2018-06-20 /pmc/articles/PMC6039842/ /pubmed/30003035 http://dx.doi.org/10.1016/j.nicl.2018.06.022 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Jung, Won-Mo
Ryu, Yeonhee
Park, Hi-Joon
Lee, Hyejung
Chae, Younbyoung
Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title_full Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title_fullStr Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title_full_unstemmed Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title_short Brain activation during the expectations of sensory experience for cutaneous electrical stimulation
title_sort brain activation during the expectations of sensory experience for cutaneous electrical stimulation
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039842/
https://www.ncbi.nlm.nih.gov/pubmed/30003035
http://dx.doi.org/10.1016/j.nicl.2018.06.022
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