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The dynamic upper limit of human lifespan

We respond to claims by Dong et al. that human lifespan is limited below 125 years. Using the log-linear increase in mortality rates with age to predict the upper limits of human survival we find, in contrast to Dong et al., that the limit to human lifespan is historically flexible and increasing. T...

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Detalles Bibliográficos
Autores principales: Newman, Saul, Easteal, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039923/
https://www.ncbi.nlm.nih.gov/pubmed/30026910
http://dx.doi.org/10.12688/f1000research.11438.2
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author Newman, Saul
Easteal, Simon
author_facet Newman, Saul
Easteal, Simon
author_sort Newman, Saul
collection PubMed
description We respond to claims by Dong et al. that human lifespan is limited below 125 years. Using the log-linear increase in mortality rates with age to predict the upper limits of human survival we find, in contrast to Dong et al., that the limit to human lifespan is historically flexible and increasing. This discrepancy can be explained by Dong et al.’s use of data with variable sample sizes, age-biased rounding errors, and log(0) instead of log(1) values in linear regressions. Addressing these issues eliminates the proposed 125-year upper limit to human lifespan.
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spelling pubmed-60399232018-07-18 The dynamic upper limit of human lifespan Newman, Saul Easteal, Simon F1000Res Research Article We respond to claims by Dong et al. that human lifespan is limited below 125 years. Using the log-linear increase in mortality rates with age to predict the upper limits of human survival we find, in contrast to Dong et al., that the limit to human lifespan is historically flexible and increasing. This discrepancy can be explained by Dong et al.’s use of data with variable sample sizes, age-biased rounding errors, and log(0) instead of log(1) values in linear regressions. Addressing these issues eliminates the proposed 125-year upper limit to human lifespan. F1000 Research Limited 2017-06-09 /pmc/articles/PMC6039923/ /pubmed/30026910 http://dx.doi.org/10.12688/f1000research.11438.2 Text en Copyright: © 2017 Newman S and Easteal S http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Newman, Saul
Easteal, Simon
The dynamic upper limit of human lifespan
title The dynamic upper limit of human lifespan
title_full The dynamic upper limit of human lifespan
title_fullStr The dynamic upper limit of human lifespan
title_full_unstemmed The dynamic upper limit of human lifespan
title_short The dynamic upper limit of human lifespan
title_sort dynamic upper limit of human lifespan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039923/
https://www.ncbi.nlm.nih.gov/pubmed/30026910
http://dx.doi.org/10.12688/f1000research.11438.2
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