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Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis
Variants in the PLPP3 gene encoding for lipid phosphate phosphohydrolase 3 have been associated with susceptibility to atherosclerosis independently of classical risk factors. PLPP3 inactivates lysophosphatidic acid (LPA), a pro-inflammatory, pro-thrombotic product of phospholipase activity. Here we...
Autores principales: | Aldi, Silvia, Matic, Ljubica Perisic, Hamm, Gregory, van Keulen, Daniëlle, Tempel, Dennie, Holmstrøm, Kim, Szwajda, Agnieszka, Nielsen, Boye Schnack, Emilsson, Valur, Ait-Belkacem, Rima, Lengquist, Mariette, Paulsson-Berne, Gabrielle, Eriksson, Per, Lindeman, Jan H.N., Gool, Alain J., Stauber, Jonathan, Hedin, Ulf, Hurt-Camejo, Eva |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039967/ https://www.ncbi.nlm.nih.gov/pubmed/30003117 http://dx.doi.org/10.1016/j.omtm.2018.05.003 |
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