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GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants
The increasing prevalence of asthma, hay fever, and allergic sensitization in Western Germany after east-west division in 1949 and their rapid increase in East German children after re-unification in 1990 are strong indications for the role of life-style and/or environmental factors in the developme...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dustri-Verlag Dr. Karl Feistle
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040001/ https://www.ncbi.nlm.nih.gov/pubmed/30402607 http://dx.doi.org/10.5414/ALX01455E |
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author | Heinrich, J. Brüske, I. Cramer, C. Hoffmann, U. Schnappinger, M. Schaaf, B. von Berg, A. Berdel, D. Krämer, U. Lehmann, I. Herbarth, O. Borte, M. Grübl, A. Bauer, C.P. Beckmann, C. Behrendt, H. Ring, J. Koletzko, S. |
author_facet | Heinrich, J. Brüske, I. Cramer, C. Hoffmann, U. Schnappinger, M. Schaaf, B. von Berg, A. Berdel, D. Krämer, U. Lehmann, I. Herbarth, O. Borte, M. Grübl, A. Bauer, C.P. Beckmann, C. Behrendt, H. Ring, J. Koletzko, S. |
author_sort | Heinrich, J. |
collection | PubMed |
description | The increasing prevalence of asthma, hay fever, and allergic sensitization in Western Germany after east-west division in 1949 and their rapid increase in East German children after re-unification in 1990 are strong indications for the role of life-style and/or environmental factors in the development of atopic diseases. Obviously, the perinatal period is crucial for priming the immune system. Therefore, explorations of determinants of atopic diseases need pregnancy or birth cohorts as the most appropriate epidemiological study designs. This review presents the design and selected results of the two German birth cohorts GINIplus and LISAplus. GINIplus and LISAplus recruited 5.991 and 3.097 healthy, term newborns, respectively, from Munich, Wesel, Leipzig, and Bad Honnef. Approximately 55% could be followed for the first 10 years. We analyzed the natural course of atopic diseases and the role of life-style, environmental, and genetic factors for disease onset, intermediate phenotypes, and genes involved in detoxification and oxidative stress. The results of these two large birth cohorts contributed substantially to the understanding of atopic diseases and their determinants. |
format | Online Article Text |
id | pubmed-6040001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dustri-Verlag Dr. Karl Feistle |
record_format | MEDLINE/PubMed |
spelling | pubmed-60400012018-11-06 GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants Heinrich, J. Brüske, I. Cramer, C. Hoffmann, U. Schnappinger, M. Schaaf, B. von Berg, A. Berdel, D. Krämer, U. Lehmann, I. Herbarth, O. Borte, M. Grübl, A. Bauer, C.P. Beckmann, C. Behrendt, H. Ring, J. Koletzko, S. Allergol Select Review Article The increasing prevalence of asthma, hay fever, and allergic sensitization in Western Germany after east-west division in 1949 and their rapid increase in East German children after re-unification in 1990 are strong indications for the role of life-style and/or environmental factors in the development of atopic diseases. Obviously, the perinatal period is crucial for priming the immune system. Therefore, explorations of determinants of atopic diseases need pregnancy or birth cohorts as the most appropriate epidemiological study designs. This review presents the design and selected results of the two German birth cohorts GINIplus and LISAplus. GINIplus and LISAplus recruited 5.991 and 3.097 healthy, term newborns, respectively, from Munich, Wesel, Leipzig, and Bad Honnef. Approximately 55% could be followed for the first 10 years. We analyzed the natural course of atopic diseases and the role of life-style, environmental, and genetic factors for disease onset, intermediate phenotypes, and genes involved in detoxification and oxidative stress. The results of these two large birth cohorts contributed substantially to the understanding of atopic diseases and their determinants. Dustri-Verlag Dr. Karl Feistle 2017-08-04 /pmc/articles/PMC6040001/ /pubmed/30402607 http://dx.doi.org/10.5414/ALX01455E Text en © Dustri-Verlag Dr. K. Feistle http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Heinrich, J. Brüske, I. Cramer, C. Hoffmann, U. Schnappinger, M. Schaaf, B. von Berg, A. Berdel, D. Krämer, U. Lehmann, I. Herbarth, O. Borte, M. Grübl, A. Bauer, C.P. Beckmann, C. Behrendt, H. Ring, J. Koletzko, S. GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title | GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title_full | GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title_fullStr | GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title_full_unstemmed | GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title_short | GINIplus and LISAplus – Design and selected results of two German birth cohorts about natural course of atopic diseases and their determinants |
title_sort | giniplus and lisaplus – design and selected results of two german birth cohorts about natural course of atopic diseases and their determinants |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040001/ https://www.ncbi.nlm.nih.gov/pubmed/30402607 http://dx.doi.org/10.5414/ALX01455E |
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