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The influence of antibiotics and dietary components on gut microbiota
The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions b...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040098/ https://www.ncbi.nlm.nih.gov/pubmed/30002765 http://dx.doi.org/10.5114/pg.2018.76005 |
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author | Dudek-Wicher, Ruth K. Junka, Adam Bartoszewicz, Marzenna |
author_facet | Dudek-Wicher, Ruth K. Junka, Adam Bartoszewicz, Marzenna |
author_sort | Dudek-Wicher, Ruth K. |
collection | PubMed |
description | The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions between resident microorganisms and the gastrointestinal tract significantly contribute to maintaining gut homeostasis. The present review summarizes our knowledge regarding the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp. Also, food additives, such as emulsifiers and artificial sweeteners, which are meant to reduce the risk of obesity and diabetes, may actually increase the risk of diseases due to microbial alterations. On the other hand, dietary components such as polyphenols, omega-3 acids or curcumin may positively affect gut microbiota composition. |
format | Online Article Text |
id | pubmed-6040098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-60400982018-07-12 The influence of antibiotics and dietary components on gut microbiota Dudek-Wicher, Ruth K. Junka, Adam Bartoszewicz, Marzenna Prz Gastroenterol Review Paper The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions between resident microorganisms and the gastrointestinal tract significantly contribute to maintaining gut homeostasis. The present review summarizes our knowledge regarding the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp. Also, food additives, such as emulsifiers and artificial sweeteners, which are meant to reduce the risk of obesity and diabetes, may actually increase the risk of diseases due to microbial alterations. On the other hand, dietary components such as polyphenols, omega-3 acids or curcumin may positively affect gut microbiota composition. Termedia Publishing House 2018-05-25 2018 /pmc/articles/PMC6040098/ /pubmed/30002765 http://dx.doi.org/10.5114/pg.2018.76005 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Review Paper Dudek-Wicher, Ruth K. Junka, Adam Bartoszewicz, Marzenna The influence of antibiotics and dietary components on gut microbiota |
title | The influence of antibiotics and dietary components on gut microbiota |
title_full | The influence of antibiotics and dietary components on gut microbiota |
title_fullStr | The influence of antibiotics and dietary components on gut microbiota |
title_full_unstemmed | The influence of antibiotics and dietary components on gut microbiota |
title_short | The influence of antibiotics and dietary components on gut microbiota |
title_sort | influence of antibiotics and dietary components on gut microbiota |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040098/ https://www.ncbi.nlm.nih.gov/pubmed/30002765 http://dx.doi.org/10.5114/pg.2018.76005 |
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