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The influence of antibiotics and dietary components on gut microbiota

The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions b...

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Autores principales: Dudek-Wicher, Ruth K., Junka, Adam, Bartoszewicz, Marzenna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040098/
https://www.ncbi.nlm.nih.gov/pubmed/30002765
http://dx.doi.org/10.5114/pg.2018.76005
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author Dudek-Wicher, Ruth K.
Junka, Adam
Bartoszewicz, Marzenna
author_facet Dudek-Wicher, Ruth K.
Junka, Adam
Bartoszewicz, Marzenna
author_sort Dudek-Wicher, Ruth K.
collection PubMed
description The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions between resident microorganisms and the gastrointestinal tract significantly contribute to maintaining gut homeostasis. The present review summarizes our knowledge regarding the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp. Also, food additives, such as emulsifiers and artificial sweeteners, which are meant to reduce the risk of obesity and diabetes, may actually increase the risk of diseases due to microbial alterations. On the other hand, dietary components such as polyphenols, omega-3 acids or curcumin may positively affect gut microbiota composition.
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spelling pubmed-60400982018-07-12 The influence of antibiotics and dietary components on gut microbiota Dudek-Wicher, Ruth K. Junka, Adam Bartoszewicz, Marzenna Prz Gastroenterol Review Paper The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions between resident microorganisms and the gastrointestinal tract significantly contribute to maintaining gut homeostasis. The present review summarizes our knowledge regarding the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp. Also, food additives, such as emulsifiers and artificial sweeteners, which are meant to reduce the risk of obesity and diabetes, may actually increase the risk of diseases due to microbial alterations. On the other hand, dietary components such as polyphenols, omega-3 acids or curcumin may positively affect gut microbiota composition. Termedia Publishing House 2018-05-25 2018 /pmc/articles/PMC6040098/ /pubmed/30002765 http://dx.doi.org/10.5114/pg.2018.76005 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Dudek-Wicher, Ruth K.
Junka, Adam
Bartoszewicz, Marzenna
The influence of antibiotics and dietary components on gut microbiota
title The influence of antibiotics and dietary components on gut microbiota
title_full The influence of antibiotics and dietary components on gut microbiota
title_fullStr The influence of antibiotics and dietary components on gut microbiota
title_full_unstemmed The influence of antibiotics and dietary components on gut microbiota
title_short The influence of antibiotics and dietary components on gut microbiota
title_sort influence of antibiotics and dietary components on gut microbiota
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040098/
https://www.ncbi.nlm.nih.gov/pubmed/30002765
http://dx.doi.org/10.5114/pg.2018.76005
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