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The effect of metformin on morphine analgesic tolerance and dependence in rats
Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in rats. For induction of tolerance, morphine sulfat...
Autores principales: | Fatemi, Iman, Amirteimoury, Morteza, Shamsizadeh, Ali, Kaeidi, Ayat |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040165/ https://www.ncbi.nlm.nih.gov/pubmed/30065764 http://dx.doi.org/10.4103/1735-5362.235158 |
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