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Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations
Gastrointestinal stromal tumor (GIST) is a refractory disease in need of novel efficacious therapy. The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-res...
Autores principales: | Miyake, Kentaro, Kawaguchi, Kei, Miyake, Masuyo, Zhao, Ming, Kiyuna, Tasuku, Igarashi, Kentaro, Zhang, Zhiying, Murakami, Takashi, Li, Yunfeng, Nelson, Scott D., Bouvet, Michael, Elliott, Irmina, Russell, Tara A., Singh, Arun S., Hiroshima, Yukihiko, Momiyama, Masashi, Matsuyama, Ryusei, Chishima, Takashi, Singh, Shree Ram, Endo, Itaru, Eilber, Fritz C., Hoffman, Robert M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040627/ https://www.ncbi.nlm.nih.gov/pubmed/30003151 http://dx.doi.org/10.1016/j.heliyon.2018.e00643 |
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