Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We first tested whether SYNJ1 contributes to phenotypic variations in familial Alzheimer’s disease (FAD) and show that SYNJ1 polymorphisms are associated with age of onset in both early- and late-onset h...

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Detalles Bibliográficos
Autores principales: Miranda, Andre M., Herman, Mathieu, Cheng, Rong, Nahmani, Eden, Barrett, Geoffrey, Micevska, Elizabeta, Fontaine, Gaelle, Potier, Marie-Claude, Head, Elizabeth, Schmitt, Frederick A., Lott, Ira T., Jiménez-Velázquez, Ivonne Z., Antonarakis, Stylianos E., Paolo, Gilbert Di, Lee, Joseph H., Hussaini, S. Abid, Marquer, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040810/
https://www.ncbi.nlm.nih.gov/pubmed/29874583
http://dx.doi.org/10.1016/j.celrep.2018.05.011

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