Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis

BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an important role in the development of T helper ty...

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Autores principales: Behfarjam, Farinaz, Jadali, Zohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040925/
https://www.ncbi.nlm.nih.gov/pubmed/30013759
http://dx.doi.org/10.15171/mejdd.2018.98
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author Behfarjam, Farinaz
Jadali, Zohreh
author_facet Behfarjam, Farinaz
Jadali, Zohreh
author_sort Behfarjam, Farinaz
collection PubMed
description BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an important role in the development of T helper type 22 (Th22) cells as major producers of IL-22. The aim of the present study was to examine the expression of aryl hydrocarbon receptor in patients with AIH and in normal controls. METHODS Levels of mRNA transcripts were measured in the peripheral blood mononuclear cells of 18 patients with AIH and compared with 18 normal controls by a quantitative real-time polymerase chain reaction. RESULTS mRNA expression of aryl hydrocarbon receptor was significantly higher in patients with AIH compared with the healthy control group (P = 0.006). CONCLUSION Th22 cells may play an important role in the pathogenesis of AIH.
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spelling pubmed-60409252018-07-16 Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis Behfarjam, Farinaz Jadali, Zohreh Middle East J Dig Dis Brief Report BACKGROUND Previous studies have indicated an elevated level of serum Interleukin (IL)-22 in patients with autoimmune hepatitis (AIH). However, there are no experimental data on the master transcription factor (aryl hydrocarbon receptor) that plays an important role in the development of T helper type 22 (Th22) cells as major producers of IL-22. The aim of the present study was to examine the expression of aryl hydrocarbon receptor in patients with AIH and in normal controls. METHODS Levels of mRNA transcripts were measured in the peripheral blood mononuclear cells of 18 patients with AIH and compared with 18 normal controls by a quantitative real-time polymerase chain reaction. RESULTS mRNA expression of aryl hydrocarbon receptor was significantly higher in patients with AIH compared with the healthy control group (P = 0.006). CONCLUSION Th22 cells may play an important role in the pathogenesis of AIH. Iranian Association of Gastroerterology and Hepatology 2018-04 2018-03-29 /pmc/articles/PMC6040925/ /pubmed/30013759 http://dx.doi.org/10.15171/mejdd.2018.98 Text en © 2018 The Author(s) This work is published by Middle East Journal of Digestive Diseaes as an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Brief Report
Behfarjam, Farinaz
Jadali, Zohreh
Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title_full Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title_fullStr Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title_full_unstemmed Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title_short Increased Expression of Aryl Hydrocarbon Receptor in Peripheral Blood Mononuclear Cells of Patients with Autoimmune Hepatitis
title_sort increased expression of aryl hydrocarbon receptor in peripheral blood mononuclear cells of patients with autoimmune hepatitis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040925/
https://www.ncbi.nlm.nih.gov/pubmed/30013759
http://dx.doi.org/10.15171/mejdd.2018.98
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