Discovery of a drug candidate for GLIS3-associated diabetes

GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GLIS3(−/−) β-like cells have been unsuccessful. Here, we develop a “minimal component” pro...

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Detalles Bibliográficos
Autores principales: Amin, Sadaf, Cook, Brandoch, Zhou, Ting, Ghazizadeh, Zaniar, Lis, Raphael, Zhang, Tuo, Khalaj, Mona, Crespo, Miguel, Perera, Manuradhi, Xiang, Jenny Zhaoying, Zhu, Zengrong, Tomishima, Mark, Liu, Chengyang, Naji, Ali, Evans, Todd, Huangfu, Danwei, Chen, Shuibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041295/
https://www.ncbi.nlm.nih.gov/pubmed/29992946
http://dx.doi.org/10.1038/s41467-018-04918-x

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