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Exploring pancreatic pathology in Plasmodium falciparum malaria patients
Hypoglycaemia is an important complication of Plasmodium falciparum malaria infection, which can be lethal if not treated. A decrease in blood sugar (BS) level has been correlated with disease severity, parasitaemia and the use of certain antimalarial drugs. This study explored the relationship betw...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041343/ https://www.ncbi.nlm.nih.gov/pubmed/29993021 http://dx.doi.org/10.1038/s41598-018-28797-w |
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author | Glaharn, Supattra Punsawad, Chuchard Ward, Stephen A. Viriyavejakul, Parnpen |
author_facet | Glaharn, Supattra Punsawad, Chuchard Ward, Stephen A. Viriyavejakul, Parnpen |
author_sort | Glaharn, Supattra |
collection | PubMed |
description | Hypoglycaemia is an important complication of Plasmodium falciparum malaria infection, which can be lethal if not treated. A decrease in blood sugar (BS) level has been correlated with disease severity, parasitaemia and the use of certain antimalarial drugs. This study explored the relationship between pancreatic pathology, including the expressions of insulin and glucagon in the islets of Langerhans, and the BS levels in P. falciparum malaria patients. Pancreatic tissues from malaria patients were divided into three groups, namely those with BS < 40 mg/dl, BS = 40–120 mg/dl, and BS > 120 mg/dl. In P. falciparum malaria, pancreatic tissues showed numerous parasitised red blood cells (PRBCs) in the capillaries, oedema, acinar necrosis and the presence of inflammatory cells. The islet size and the expression of insulin were significantly increased in P. falciparum malaria patients with hypoglycaemia. In addition, insulin expression was positively correlated with islet size and negatively correlated with BS levels. This pioneer study documents an increase in insulin expression and an increase in islet size in hypoglycaemic patients with P. falciparum malaria. This could contribute to the pathogenesis of hypoglycaemia and provides evidence for the potential need to effectively manage the hypoglycaemia seen in malaria infection. |
format | Online Article Text |
id | pubmed-6041343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60413432018-07-13 Exploring pancreatic pathology in Plasmodium falciparum malaria patients Glaharn, Supattra Punsawad, Chuchard Ward, Stephen A. Viriyavejakul, Parnpen Sci Rep Article Hypoglycaemia is an important complication of Plasmodium falciparum malaria infection, which can be lethal if not treated. A decrease in blood sugar (BS) level has been correlated with disease severity, parasitaemia and the use of certain antimalarial drugs. This study explored the relationship between pancreatic pathology, including the expressions of insulin and glucagon in the islets of Langerhans, and the BS levels in P. falciparum malaria patients. Pancreatic tissues from malaria patients were divided into three groups, namely those with BS < 40 mg/dl, BS = 40–120 mg/dl, and BS > 120 mg/dl. In P. falciparum malaria, pancreatic tissues showed numerous parasitised red blood cells (PRBCs) in the capillaries, oedema, acinar necrosis and the presence of inflammatory cells. The islet size and the expression of insulin were significantly increased in P. falciparum malaria patients with hypoglycaemia. In addition, insulin expression was positively correlated with islet size and negatively correlated with BS levels. This pioneer study documents an increase in insulin expression and an increase in islet size in hypoglycaemic patients with P. falciparum malaria. This could contribute to the pathogenesis of hypoglycaemia and provides evidence for the potential need to effectively manage the hypoglycaemia seen in malaria infection. Nature Publishing Group UK 2018-07-11 /pmc/articles/PMC6041343/ /pubmed/29993021 http://dx.doi.org/10.1038/s41598-018-28797-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Glaharn, Supattra Punsawad, Chuchard Ward, Stephen A. Viriyavejakul, Parnpen Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title | Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title_full | Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title_fullStr | Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title_full_unstemmed | Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title_short | Exploring pancreatic pathology in Plasmodium falciparum malaria patients |
title_sort | exploring pancreatic pathology in plasmodium falciparum malaria patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041343/ https://www.ncbi.nlm.nih.gov/pubmed/29993021 http://dx.doi.org/10.1038/s41598-018-28797-w |
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