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Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder
White-spotted flower chafer (Protaetia brevitarsis) is an edible insect and its larva was used as a traditional Asian medicine. It’s a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041370/ https://www.ncbi.nlm.nih.gov/pubmed/30003048 http://dx.doi.org/10.1016/j.toxrep.2018.06.001 |
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author | Noh, Jung-Ho Jeong, Ji-Seong Park, Sang-Jin Yun, Eun-Young Hwang, Jae Sam Kim, Ji-Young Jung, Kyung-Jin Park, Hee Jin Son, Hwa-Young Moon, Kyoung-Sik |
author_facet | Noh, Jung-Ho Jeong, Ji-Seong Park, Sang-Jin Yun, Eun-Young Hwang, Jae Sam Kim, Ji-Young Jung, Kyung-Jin Park, Hee Jin Son, Hwa-Young Moon, Kyoung-Sik |
author_sort | Noh, Jung-Ho |
collection | PubMed |
description | White-spotted flower chafer (Protaetia brevitarsis) is an edible insect and its larva was used as a traditional Asian medicine. It’s a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicity of freeze-dried P. brevitarsis larva powder to develop a novel food material. In a single-dose oral toxicity study in rats, there were no changes in mortality, clinical observations, and body weight in rats administered 5000 mg/kg P. brevitarsis larva powder. In a 13-week oral repeated dose toxicity study in rats, there were no adverse effects or changes in mortality, clinical observations, body weight, food consumption, ophthalmology, clinical pathology, necropsy, organ weight, and histopathology at doses of 300, 1000, and 3000 mg/kg/day. In identification of allergic reactions, P. brevitarsis larva powder induced no increases of serum immunoglobulin E and histamine concentrations over 13 weeks of oral administration in rats. In a genotoxicity assessment, P. brevitarsis larva powder didn’t provoke bacterial reverse mutations, chromosomal aberrations, and micronucleated reticulocytes. Therefore, freeze-dried P. brevitarsis larva powder shows no evidence of toxic and mutagenic changes under the experimental conditions of the present in vitro and in vivo studies. |
format | Online Article Text |
id | pubmed-6041370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60413702018-07-12 Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder Noh, Jung-Ho Jeong, Ji-Seong Park, Sang-Jin Yun, Eun-Young Hwang, Jae Sam Kim, Ji-Young Jung, Kyung-Jin Park, Hee Jin Son, Hwa-Young Moon, Kyoung-Sik Toxicol Rep Article White-spotted flower chafer (Protaetia brevitarsis) is an edible insect and its larva was used as a traditional Asian medicine. It’s a promising material as a novel food source because of its nutritional components. In this study, as part of the preclinical toxicity program, we evaluated the toxicity of freeze-dried P. brevitarsis larva powder to develop a novel food material. In a single-dose oral toxicity study in rats, there were no changes in mortality, clinical observations, and body weight in rats administered 5000 mg/kg P. brevitarsis larva powder. In a 13-week oral repeated dose toxicity study in rats, there were no adverse effects or changes in mortality, clinical observations, body weight, food consumption, ophthalmology, clinical pathology, necropsy, organ weight, and histopathology at doses of 300, 1000, and 3000 mg/kg/day. In identification of allergic reactions, P. brevitarsis larva powder induced no increases of serum immunoglobulin E and histamine concentrations over 13 weeks of oral administration in rats. In a genotoxicity assessment, P. brevitarsis larva powder didn’t provoke bacterial reverse mutations, chromosomal aberrations, and micronucleated reticulocytes. Therefore, freeze-dried P. brevitarsis larva powder shows no evidence of toxic and mutagenic changes under the experimental conditions of the present in vitro and in vivo studies. Elsevier 2018-06-02 /pmc/articles/PMC6041370/ /pubmed/30003048 http://dx.doi.org/10.1016/j.toxrep.2018.06.001 Text en © 2018 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Noh, Jung-Ho Jeong, Ji-Seong Park, Sang-Jin Yun, Eun-Young Hwang, Jae Sam Kim, Ji-Young Jung, Kyung-Jin Park, Hee Jin Son, Hwa-Young Moon, Kyoung-Sik Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title | Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title_full | Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title_fullStr | Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title_full_unstemmed | Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title_short | Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder |
title_sort | toxicological safety evaluation of freeze-dried protaetia brevitarsis larva powder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041370/ https://www.ncbi.nlm.nih.gov/pubmed/30003048 http://dx.doi.org/10.1016/j.toxrep.2018.06.001 |
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