Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA

Autoantibodies against double-stranded DNA (anti-dsDNA) are a hallmark of systemic lupus erythematosus (SLE). It is well documented that anti-dsDNA reactive B lymphocytes are normally controlled by immune self-tolerance mechanisms operating at several levels. The evolution of high levels of IgG anti...

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Detalles Bibliográficos
Autores principales: Weisenburger, Thomas, von Neubeck, Bettina, Schneider, Andrea, Ebert, Nadja, Schreyer, Daniel, Acs, Andreas, Winkler, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041390/
https://www.ncbi.nlm.nih.gov/pubmed/30026744
http://dx.doi.org/10.3389/fimmu.2018.01551

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