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The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts

Defining functional domains and amino acid residues in G protein coupled receptors (GPCRs) represent an important way to improve rational drug design for this major class of drug targets. The cannabinoid type 1 (CB1) receptor is one of the most abundant GPCRs in the central nervous system and is inv...

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Detalles Bibliográficos
Autores principales:	Wickert, Melanie, Hildick, Keri L., Baillie, Gemma L., Jelinek, Ruth, Aparisi Rey, Alejandro, Monory, Krisztina, Schneider, Miriam, Ross, Ruth A., Henley, Jeremy M., Lutz, Beat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041392/ https://www.ncbi.nlm.nih.gov/pubmed/30026687 http://dx.doi.org/10.3389/fnmol.2018.00230

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