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The neuropsychological profiles and semantic-critical regions of right semantic dementia
INTRODUCTION: Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. METHODS: Seventeen patients with right-sided SD, 18 patients with left-sided SD and...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041419/ https://www.ncbi.nlm.nih.gov/pubmed/30009130 http://dx.doi.org/10.1016/j.nicl.2018.05.035 |
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author | Chen, Keliang Ding, Junhua Lin, Biying Huang, Lin Tang, Le Bi, Yanchao Han, Zaizhu Lv, Yingru Guo, Qihao |
author_facet | Chen, Keliang Ding, Junhua Lin, Biying Huang, Lin Tang, Le Bi, Yanchao Han, Zaizhu Lv, Yingru Guo, Qihao |
author_sort | Chen, Keliang |
collection | PubMed |
description | INTRODUCTION: Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. METHODS: Seventeen patients with right-sided SD, 18 patients with left-sided SD and 20 normal controls (NC) underwent neuropsychological assessments and magnetic resonance imaging scans. We investigated the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in left and right-sided SD samples, respectively. RESULTS: We found the semantic deficits of right-sided SD patients were related to bilateral fusiform gyri and left temporal pole, whilst the left fusiform gyrus correlated with the semantic performance of left-sided SD patients. Moreover, all the findings couldn't be accounted for by total gray matter volume (GMV) or general cognitive degradation of patients. DISCUSSION: These results provide novel evidence for the current semantic theory, that the important regions for semantic processing include both anterior and posterior temporal lobes. |
format | Online Article Text |
id | pubmed-6041419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60414192018-07-13 The neuropsychological profiles and semantic-critical regions of right semantic dementia Chen, Keliang Ding, Junhua Lin, Biying Huang, Lin Tang, Le Bi, Yanchao Han, Zaizhu Lv, Yingru Guo, Qihao Neuroimage Clin Regular Article INTRODUCTION: Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. METHODS: Seventeen patients with right-sided SD, 18 patients with left-sided SD and 20 normal controls (NC) underwent neuropsychological assessments and magnetic resonance imaging scans. We investigated the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in left and right-sided SD samples, respectively. RESULTS: We found the semantic deficits of right-sided SD patients were related to bilateral fusiform gyri and left temporal pole, whilst the left fusiform gyrus correlated with the semantic performance of left-sided SD patients. Moreover, all the findings couldn't be accounted for by total gray matter volume (GMV) or general cognitive degradation of patients. DISCUSSION: These results provide novel evidence for the current semantic theory, that the important regions for semantic processing include both anterior and posterior temporal lobes. Elsevier 2018-05-29 /pmc/articles/PMC6041419/ /pubmed/30009130 http://dx.doi.org/10.1016/j.nicl.2018.05.035 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Chen, Keliang Ding, Junhua Lin, Biying Huang, Lin Tang, Le Bi, Yanchao Han, Zaizhu Lv, Yingru Guo, Qihao The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title | The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title_full | The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title_fullStr | The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title_full_unstemmed | The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title_short | The neuropsychological profiles and semantic-critical regions of right semantic dementia |
title_sort | neuropsychological profiles and semantic-critical regions of right semantic dementia |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041419/ https://www.ncbi.nlm.nih.gov/pubmed/30009130 http://dx.doi.org/10.1016/j.nicl.2018.05.035 |
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