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Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine res...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041420/ https://www.ncbi.nlm.nih.gov/pubmed/30009247 http://dx.doi.org/10.1016/j.plabm.2018.e00104 |
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author | Feng, Sheng Cummings, Oneka McIntire, Gregory |
author_facet | Feng, Sheng Cummings, Oneka McIntire, Gregory |
author_sort | Feng, Sheng |
collection | PubMed |
description | Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine results available from pain medication monitoring. Additionally, test results from patients using a nicotine transdermal patch delivery device are compared with those from smokers. Finally, oral fluid test results collected over a 2-year period were normalized and transformed to yield a near Gaussian distribution for nicotine. The normalized and transformed data reveal the presence of two independent populations: a larger population consistent with active smokers and a smaller population consistent with those passively exposed to smoke. Furthermore, application of this model to patients prescribed transdermal nicotine reveals oral fluid levels consistent with those of active smokers. The clinical delineation of smokers from non-smokers reported earlier is supported by the oral fluid nicotine data modelling presented herein. These data indicate that oral fluid is an acceptable sample matrix for determining the smoking status of patients. Further, these data indicate that oral fluid test results are indistinguishable between patients prescribed transdermal patches and active smokers; however, oral fluid testing can determine absence of patches or smoking. |
format | Online Article Text |
id | pubmed-6041420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60414202018-07-13 Nicotine and cotinine in oral fluid: Passive exposure vs active smoking Feng, Sheng Cummings, Oneka McIntire, Gregory Pract Lab Med Article Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine results available from pain medication monitoring. Additionally, test results from patients using a nicotine transdermal patch delivery device are compared with those from smokers. Finally, oral fluid test results collected over a 2-year period were normalized and transformed to yield a near Gaussian distribution for nicotine. The normalized and transformed data reveal the presence of two independent populations: a larger population consistent with active smokers and a smaller population consistent with those passively exposed to smoke. Furthermore, application of this model to patients prescribed transdermal nicotine reveals oral fluid levels consistent with those of active smokers. The clinical delineation of smokers from non-smokers reported earlier is supported by the oral fluid nicotine data modelling presented herein. These data indicate that oral fluid is an acceptable sample matrix for determining the smoking status of patients. Further, these data indicate that oral fluid test results are indistinguishable between patients prescribed transdermal patches and active smokers; however, oral fluid testing can determine absence of patches or smoking. Elsevier 2018-05-28 /pmc/articles/PMC6041420/ /pubmed/30009247 http://dx.doi.org/10.1016/j.plabm.2018.e00104 Text en © 2018 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Feng, Sheng Cummings, Oneka McIntire, Gregory Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title | Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title_full | Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title_fullStr | Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title_full_unstemmed | Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title_short | Nicotine and cotinine in oral fluid: Passive exposure vs active smoking |
title_sort | nicotine and cotinine in oral fluid: passive exposure vs active smoking |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041420/ https://www.ncbi.nlm.nih.gov/pubmed/30009247 http://dx.doi.org/10.1016/j.plabm.2018.e00104 |
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