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Nicotine and cotinine in oral fluid: Passive exposure vs active smoking

Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine res...

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Detalles Bibliográficos
Autores principales: Feng, Sheng, Cummings, Oneka, McIntire, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041420/
https://www.ncbi.nlm.nih.gov/pubmed/30009247
http://dx.doi.org/10.1016/j.plabm.2018.e00104
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author Feng, Sheng
Cummings, Oneka
McIntire, Gregory
author_facet Feng, Sheng
Cummings, Oneka
McIntire, Gregory
author_sort Feng, Sheng
collection PubMed
description Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine results available from pain medication monitoring. Additionally, test results from patients using a nicotine transdermal patch delivery device are compared with those from smokers. Finally, oral fluid test results collected over a 2-year period were normalized and transformed to yield a near Gaussian distribution for nicotine. The normalized and transformed data reveal the presence of two independent populations: a larger population consistent with active smokers and a smaller population consistent with those passively exposed to smoke. Furthermore, application of this model to patients prescribed transdermal nicotine reveals oral fluid levels consistent with those of active smokers. The clinical delineation of smokers from non-smokers reported earlier is supported by the oral fluid nicotine data modelling presented herein. These data indicate that oral fluid is an acceptable sample matrix for determining the smoking status of patients. Further, these data indicate that oral fluid test results are indistinguishable between patients prescribed transdermal patches and active smokers; however, oral fluid testing can determine absence of patches or smoking.
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spelling pubmed-60414202018-07-13 Nicotine and cotinine in oral fluid: Passive exposure vs active smoking Feng, Sheng Cummings, Oneka McIntire, Gregory Pract Lab Med Article Scheidweiler and colleagues have clinically tested and identified a reporting cutoff (10 ng/mL) of nicotine and cotinine in oral fluid that could reliably determine active smoking in patients. The results from that study were reevaluated using a large data set of oral fluid nicotine and cotinine results available from pain medication monitoring. Additionally, test results from patients using a nicotine transdermal patch delivery device are compared with those from smokers. Finally, oral fluid test results collected over a 2-year period were normalized and transformed to yield a near Gaussian distribution for nicotine. The normalized and transformed data reveal the presence of two independent populations: a larger population consistent with active smokers and a smaller population consistent with those passively exposed to smoke. Furthermore, application of this model to patients prescribed transdermal nicotine reveals oral fluid levels consistent with those of active smokers. The clinical delineation of smokers from non-smokers reported earlier is supported by the oral fluid nicotine data modelling presented herein. These data indicate that oral fluid is an acceptable sample matrix for determining the smoking status of patients. Further, these data indicate that oral fluid test results are indistinguishable between patients prescribed transdermal patches and active smokers; however, oral fluid testing can determine absence of patches or smoking. Elsevier 2018-05-28 /pmc/articles/PMC6041420/ /pubmed/30009247 http://dx.doi.org/10.1016/j.plabm.2018.e00104 Text en © 2018 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Feng, Sheng
Cummings, Oneka
McIntire, Gregory
Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title_full Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title_fullStr Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title_full_unstemmed Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title_short Nicotine and cotinine in oral fluid: Passive exposure vs active smoking
title_sort nicotine and cotinine in oral fluid: passive exposure vs active smoking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041420/
https://www.ncbi.nlm.nih.gov/pubmed/30009247
http://dx.doi.org/10.1016/j.plabm.2018.e00104
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