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Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia

Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains is helpful to understand this disease. Thus, we first used the minimum Redundancy-Maximum Relevance (mRMR) approach to integrate the genome-wide sequence analysis results on SCZ and the expre...

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Autores principales: Cai, Lei, Huang, Tao, Su, Jingjing, Zhang, Xinxin, Chen, Wenzhong, Zhang, Fuquan, He, Lin, Chou, Kuo-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041437/
https://www.ncbi.nlm.nih.gov/pubmed/30195780
http://dx.doi.org/10.1016/j.omtn.2018.05.026
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author Cai, Lei
Huang, Tao
Su, Jingjing
Zhang, Xinxin
Chen, Wenzhong
Zhang, Fuquan
He, Lin
Chou, Kuo-Chen
author_facet Cai, Lei
Huang, Tao
Su, Jingjing
Zhang, Xinxin
Chen, Wenzhong
Zhang, Fuquan
He, Lin
Chou, Kuo-Chen
author_sort Cai, Lei
collection PubMed
description Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains is helpful to understand this disease. Thus, we first used the minimum Redundancy-Maximum Relevance (mRMR) approach to integrate the genome-wide sequence analysis results on SCZ and the expression quantitative trait locus (eQTL) data from ten brain tissues to identify the genes related to SCZ. Second, we adopted the variance inflation factor regression algorithm to identify their interacting genes in brains. Third, using multiple analysis methods, we explored and validated their roles. By means of the aforementioned procedures, we have found that (1) the cerebellum may play a crucial role in the pathogenesis of SCZ and (2) ITIH4 may be utilized as a clinical biomarker for the diagnosis of SCZ. These interesting findings may stimulate novel strategy for developing new drugs against SCZ. It has not escaped our notice that the approach reported here is of use for studying many other genome diseases as well.
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spelling pubmed-60414372018-07-12 Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia Cai, Lei Huang, Tao Su, Jingjing Zhang, Xinxin Chen, Wenzhong Zhang, Fuquan He, Lin Chou, Kuo-Chen Mol Ther Nucleic Acids Article Schizophrenia (SCZ) is a devastating genetic mental disorder. Identification of the SCZ risk genes in brains is helpful to understand this disease. Thus, we first used the minimum Redundancy-Maximum Relevance (mRMR) approach to integrate the genome-wide sequence analysis results on SCZ and the expression quantitative trait locus (eQTL) data from ten brain tissues to identify the genes related to SCZ. Second, we adopted the variance inflation factor regression algorithm to identify their interacting genes in brains. Third, using multiple analysis methods, we explored and validated their roles. By means of the aforementioned procedures, we have found that (1) the cerebellum may play a crucial role in the pathogenesis of SCZ and (2) ITIH4 may be utilized as a clinical biomarker for the diagnosis of SCZ. These interesting findings may stimulate novel strategy for developing new drugs against SCZ. It has not escaped our notice that the approach reported here is of use for studying many other genome diseases as well. American Society of Gene & Cell Therapy 2018-07-11 /pmc/articles/PMC6041437/ /pubmed/30195780 http://dx.doi.org/10.1016/j.omtn.2018.05.026 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Cai, Lei
Huang, Tao
Su, Jingjing
Zhang, Xinxin
Chen, Wenzhong
Zhang, Fuquan
He, Lin
Chou, Kuo-Chen
Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title_full Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title_fullStr Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title_full_unstemmed Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title_short Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia
title_sort implications of newly identified brain eqtl genes and their interactors in schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041437/
https://www.ncbi.nlm.nih.gov/pubmed/30195780
http://dx.doi.org/10.1016/j.omtn.2018.05.026
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