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Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study

Background: Pancreatic cancer is a difficult-to-treat cancer with a late presentation and poor prognosis. Some patients seek traditional Chinese medicine (TCM) consultation. We aimed to investigate the benefits of complementary Chinese herbal medicine (CHM) among patients with pancreatic cancer in T...

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Autores principales: Kuo, Yi-Ting, Liao, Hou-Hsun, Chiang, Jen-Huai, Wu, Mei-Yao, Chen, Bor-Chyuan, Chang, Ching-Mao, Yeh, Ming-Hsien, Chang, Tung-Ti, Sun, Mao-Feng, Yeh, Chia-Chou, Yen, Hung-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041895/
https://www.ncbi.nlm.nih.gov/pubmed/28774207
http://dx.doi.org/10.1177/1534735417722224
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author Kuo, Yi-Ting
Liao, Hou-Hsun
Chiang, Jen-Huai
Wu, Mei-Yao
Chen, Bor-Chyuan
Chang, Ching-Mao
Yeh, Ming-Hsien
Chang, Tung-Ti
Sun, Mao-Feng
Yeh, Chia-Chou
Yen, Hung-Rong
author_facet Kuo, Yi-Ting
Liao, Hou-Hsun
Chiang, Jen-Huai
Wu, Mei-Yao
Chen, Bor-Chyuan
Chang, Ching-Mao
Yeh, Ming-Hsien
Chang, Tung-Ti
Sun, Mao-Feng
Yeh, Chia-Chou
Yen, Hung-Rong
author_sort Kuo, Yi-Ting
collection PubMed
description Background: Pancreatic cancer is a difficult-to-treat cancer with a late presentation and poor prognosis. Some patients seek traditional Chinese medicine (TCM) consultation. We aimed to investigate the benefits of complementary Chinese herbal medicine (CHM) among patients with pancreatic cancer in Taiwan. Methods: We included all patients with pancreatic cancer who were registered in the Taiwanese Registry for Catastrophic Illness Patients Database between 1997 and 2010. We used 1:1 frequency matching by age, sex, the initial diagnostic year of pancreatic cancer, and index year to enroll 386 CHM users and 386 non-CHM users. A Cox regression model was used to compare the hazard ratios (HRs) of the risk of mortality. The Kaplan-Meier curve was used to compare the difference in survival time. Results: According to the Cox hazard ratio model mutually adjusted for CHM use, age, sex, urbanization level, comorbidity, and treatments, we found that CHM users had a lower hazard ratio of mortality risk (adjusted HR = 0.67, 95% CI = 0.56-0.79). Those who received CHM therapy for more than 90 days had significantly lower hazard ratios of mortality risk than non-CHM users (90- to 180-day group: adjusted HR = 0.56, 95% CI = 0.42-0.75; >180-day group: HR = 0.33, 95% CI = 0.24-0.45). The survival probability was higher for patients in the CHM group. Bai-hua-she-she-cao (Herba Oldenlandiae; Hedyotis diffusa Spreng) and Xiang-sha-liu-jun-zi-tang (Costus and Chinese Amomum Combination) were the most commonly used single herb and Chinese herbal formula, respectively. Conclusions: Complementary Chinese herbal therapy might be associated with reduced mortality among patients with pancreatic cancer. Further prospective clinical trial is warranted.
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spelling pubmed-60418952018-07-16 Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study Kuo, Yi-Ting Liao, Hou-Hsun Chiang, Jen-Huai Wu, Mei-Yao Chen, Bor-Chyuan Chang, Ching-Mao Yeh, Ming-Hsien Chang, Tung-Ti Sun, Mao-Feng Yeh, Chia-Chou Yen, Hung-Rong Integr Cancer Ther Research Articles Background: Pancreatic cancer is a difficult-to-treat cancer with a late presentation and poor prognosis. Some patients seek traditional Chinese medicine (TCM) consultation. We aimed to investigate the benefits of complementary Chinese herbal medicine (CHM) among patients with pancreatic cancer in Taiwan. Methods: We included all patients with pancreatic cancer who were registered in the Taiwanese Registry for Catastrophic Illness Patients Database between 1997 and 2010. We used 1:1 frequency matching by age, sex, the initial diagnostic year of pancreatic cancer, and index year to enroll 386 CHM users and 386 non-CHM users. A Cox regression model was used to compare the hazard ratios (HRs) of the risk of mortality. The Kaplan-Meier curve was used to compare the difference in survival time. Results: According to the Cox hazard ratio model mutually adjusted for CHM use, age, sex, urbanization level, comorbidity, and treatments, we found that CHM users had a lower hazard ratio of mortality risk (adjusted HR = 0.67, 95% CI = 0.56-0.79). Those who received CHM therapy for more than 90 days had significantly lower hazard ratios of mortality risk than non-CHM users (90- to 180-day group: adjusted HR = 0.56, 95% CI = 0.42-0.75; >180-day group: HR = 0.33, 95% CI = 0.24-0.45). The survival probability was higher for patients in the CHM group. Bai-hua-she-she-cao (Herba Oldenlandiae; Hedyotis diffusa Spreng) and Xiang-sha-liu-jun-zi-tang (Costus and Chinese Amomum Combination) were the most commonly used single herb and Chinese herbal formula, respectively. Conclusions: Complementary Chinese herbal therapy might be associated with reduced mortality among patients with pancreatic cancer. Further prospective clinical trial is warranted. SAGE Publications 2017-08-03 /pmc/articles/PMC6041895/ /pubmed/28774207 http://dx.doi.org/10.1177/1534735417722224 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Articles
Kuo, Yi-Ting
Liao, Hou-Hsun
Chiang, Jen-Huai
Wu, Mei-Yao
Chen, Bor-Chyuan
Chang, Ching-Mao
Yeh, Ming-Hsien
Chang, Tung-Ti
Sun, Mao-Feng
Yeh, Chia-Chou
Yen, Hung-Rong
Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title_full Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title_fullStr Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title_full_unstemmed Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title_short Complementary Chinese Herbal Medicine Therapy Improves Survival of Patients With Pancreatic Cancer in Taiwan: A Nationwide Population-Based Cohort Study
title_sort complementary chinese herbal medicine therapy improves survival of patients with pancreatic cancer in taiwan: a nationwide population-based cohort study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041895/
https://www.ncbi.nlm.nih.gov/pubmed/28774207
http://dx.doi.org/10.1177/1534735417722224
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