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SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response
Detection of nucleic acids by innate immune sensors triggers the production of type I interferons (IFNs). While IFNs are essential for host defense against viral infection, dysregulated production of IFNs underlies numerous autoinflammatory diseases. We have found that the loss of sumoylation result...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042150/ https://www.ncbi.nlm.nih.gov/pubmed/29891701 http://dx.doi.org/10.1073/pnas.1802114115 |