Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis

BACKGROUND: A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator activated receptor-γ (PPAR-γ) has antifibrotic effects by blocking transforming...

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Detalles Bibliográficos
Autores principales: Korman, Benjamin, Marangoni, Roberta Goncalves, Lord, Gabriel, Olefsky, Jerrold, Tourtellotte, Warren, Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042240/
https://www.ncbi.nlm.nih.gov/pubmed/29996896
http://dx.doi.org/10.1186/s13075-018-1630-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042240/
https://www.ncbi.nlm.nih.gov/pubmed/29996896
http://dx.doi.org/10.1186/s13075-018-1630-z

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