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Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research
BACKGROUND: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042254/ https://www.ncbi.nlm.nih.gov/pubmed/29996912 http://dx.doi.org/10.1186/s13287-018-0938-6 |
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author | Lopes, Lara Setia, Ocean Aurshina, Afsha Liu, Shirley Hu, Haidi Isaji, Toshihiko Liu, Haiyang Wang, Tun Ono, Shun Guo, Xiangjiang Yatsula, Bogdan Guo, Jianming Gu, Yongquan Navarro, Tulio Dardik, Alan |
author_facet | Lopes, Lara Setia, Ocean Aurshina, Afsha Liu, Shirley Hu, Haidi Isaji, Toshihiko Liu, Haiyang Wang, Tun Ono, Shun Guo, Xiangjiang Yatsula, Bogdan Guo, Jianming Gu, Yongquan Navarro, Tulio Dardik, Alan |
author_sort | Lopes, Lara |
collection | PubMed |
description | BACKGROUND: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. METHODS: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. RESULTS: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. CONCLUSIONS: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials. |
format | Online Article Text |
id | pubmed-6042254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60422542018-07-13 Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research Lopes, Lara Setia, Ocean Aurshina, Afsha Liu, Shirley Hu, Haidi Isaji, Toshihiko Liu, Haiyang Wang, Tun Ono, Shun Guo, Xiangjiang Yatsula, Bogdan Guo, Jianming Gu, Yongquan Navarro, Tulio Dardik, Alan Stem Cell Res Ther Research BACKGROUND: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. METHODS: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. RESULTS: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. CONCLUSIONS: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials. BioMed Central 2018-07-11 /pmc/articles/PMC6042254/ /pubmed/29996912 http://dx.doi.org/10.1186/s13287-018-0938-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Lopes, Lara Setia, Ocean Aurshina, Afsha Liu, Shirley Hu, Haidi Isaji, Toshihiko Liu, Haiyang Wang, Tun Ono, Shun Guo, Xiangjiang Yatsula, Bogdan Guo, Jianming Gu, Yongquan Navarro, Tulio Dardik, Alan Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_full | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_fullStr | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_full_unstemmed | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_short | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
title_sort | stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042254/ https://www.ncbi.nlm.nih.gov/pubmed/29996912 http://dx.doi.org/10.1186/s13287-018-0938-6 |
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