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Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control

BACKGROUND: Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are captured in the aqueous cytosol by a co-chaperone, the small glutamine-rich, tet...

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Detalles Bibliográficos
Autores principales:	Martínez-Lumbreras, Santiago, Krysztofinska, Ewelina M., Thapaliya, Arjun, Spilotros, Alessandro, Matak-Vinkovic, Dijana, Salvadori, Enrico, Roboti, Peristera, Nyathi, Yvonne, Muench, Janina H., Roessler, Maxie M., Svergun, Dmitri I., High, Stephen, Isaacson, Rivka L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042327/ https://www.ncbi.nlm.nih.gov/pubmed/29996828 http://dx.doi.org/10.1186/s12915-018-0542-3

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