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Limitations of alignment-free tools in total RNA-seq quantification

BACKGROUND: Alignment-free RNA quantification tools have significantly increased the speed of RNA-seq analysis. However, it is unclear whether these state-of-the-art RNA-seq analysis pipelines can quantify small RNAs as accurately as they do with long RNAs in the context of total RNA quantification....

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Detalles Bibliográficos
Autores principales: Wu, Douglas C., Yao, Jun, Ho, Kevin S., Lambowitz, Alan M., Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042521/
https://www.ncbi.nlm.nih.gov/pubmed/29969991
http://dx.doi.org/10.1186/s12864-018-4869-5

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