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Severe lamotrigine toxicosis in a dog
OBJECTIVE: The objective of this study was to describe a case of severe lamotrigine toxicosis in a dog, which was successfully treated using minimal medical interventions. CASE SUMMARY: A 7-month-old male, intact, Labrador mix was evaluated because of acute onset of vomiting, rigidity, and dull ment...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042642/ https://www.ncbi.nlm.nih.gov/pubmed/30050852 http://dx.doi.org/10.2147/VMRR.S131583 |
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author | Sawyer, Danielle Gates, Kathryn |
author_facet | Sawyer, Danielle Gates, Kathryn |
author_sort | Sawyer, Danielle |
collection | PubMed |
description | OBJECTIVE: The objective of this study was to describe a case of severe lamotrigine toxicosis in a dog, which was successfully treated using minimal medical interventions. CASE SUMMARY: A 7-month-old male, intact, Labrador mix was evaluated because of acute onset of vomiting, rigidity, and dull mentation after ingesting lamotrigine tablets. The estimated oral dose that had been ingested was 278 mg/kg (611.6 mg/lb). Physical examination was unremarkable other than abnormalities noted in the cardiovascular and neurological systems. Neurological examination revealed dull mentation, vertical nystagmus, four-legged extensor limb rigidity, and alligator rolling. Cardiovascular examination revealed pale pink mucous membranes and multifocal ventricular tachycardia. Intravenous (IV) fluids were started at three times maintenance (180 mL/kg/day). Methocarbamol (100 mg/kg [220 mg/lb], rectally) and lidocaine (2 mg/kg [4.4 mg/lb, IV]) were administered. Twenty-four and seventy-two hours after presentation, the dog was clinically normal with no ventricular tachycardia being noted. CONCLUSION: Lamotrigine (6-[2,3-dichlorophenyl]-1,2,4-triazine-3,5-diamine) is an anticonvulsant medication used in humans, which inhibits voltage-gated sodium channels. The clinical success of this case suggests that administration of only methocarbamol for the neurologic effects and lidocaine for the arrhythmias, as well as supportive IV fluid therapy, could be a successful treatment strategy for dogs, even with severe lamotrigine toxicosis. |
format | Online Article Text |
id | pubmed-6042642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60426422018-07-26 Severe lamotrigine toxicosis in a dog Sawyer, Danielle Gates, Kathryn Vet Med (Auckl) Case Report OBJECTIVE: The objective of this study was to describe a case of severe lamotrigine toxicosis in a dog, which was successfully treated using minimal medical interventions. CASE SUMMARY: A 7-month-old male, intact, Labrador mix was evaluated because of acute onset of vomiting, rigidity, and dull mentation after ingesting lamotrigine tablets. The estimated oral dose that had been ingested was 278 mg/kg (611.6 mg/lb). Physical examination was unremarkable other than abnormalities noted in the cardiovascular and neurological systems. Neurological examination revealed dull mentation, vertical nystagmus, four-legged extensor limb rigidity, and alligator rolling. Cardiovascular examination revealed pale pink mucous membranes and multifocal ventricular tachycardia. Intravenous (IV) fluids were started at three times maintenance (180 mL/kg/day). Methocarbamol (100 mg/kg [220 mg/lb], rectally) and lidocaine (2 mg/kg [4.4 mg/lb, IV]) were administered. Twenty-four and seventy-two hours after presentation, the dog was clinically normal with no ventricular tachycardia being noted. CONCLUSION: Lamotrigine (6-[2,3-dichlorophenyl]-1,2,4-triazine-3,5-diamine) is an anticonvulsant medication used in humans, which inhibits voltage-gated sodium channels. The clinical success of this case suggests that administration of only methocarbamol for the neurologic effects and lidocaine for the arrhythmias, as well as supportive IV fluid therapy, could be a successful treatment strategy for dogs, even with severe lamotrigine toxicosis. Dove Medical Press 2017-04-18 /pmc/articles/PMC6042642/ /pubmed/30050852 http://dx.doi.org/10.2147/VMRR.S131583 Text en © 2017 Sawyer and Gates. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Sawyer, Danielle Gates, Kathryn Severe lamotrigine toxicosis in a dog |
title | Severe lamotrigine toxicosis in a dog |
title_full | Severe lamotrigine toxicosis in a dog |
title_fullStr | Severe lamotrigine toxicosis in a dog |
title_full_unstemmed | Severe lamotrigine toxicosis in a dog |
title_short | Severe lamotrigine toxicosis in a dog |
title_sort | severe lamotrigine toxicosis in a dog |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042642/ https://www.ncbi.nlm.nih.gov/pubmed/30050852 http://dx.doi.org/10.2147/VMRR.S131583 |
work_keys_str_mv | AT sawyerdanielle severelamotriginetoxicosisinadog AT gateskathryn severelamotriginetoxicosisinadog |