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A bidirectional relationship between sleep and oxidative stress in Drosophila
Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042693/ https://www.ncbi.nlm.nih.gov/pubmed/30001323 http://dx.doi.org/10.1371/journal.pbio.2005206 |
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author | Hill, Vanessa M. O’Connor, Reed M. Sissoko, Gunter B. Irobunda, Ifeoma S. Leong, Stephen Canman, Julie C. Stavropoulos, Nicholas Shirasu-Hiza, Mimi |
author_facet | Hill, Vanessa M. O’Connor, Reed M. Sissoko, Gunter B. Irobunda, Ifeoma S. Leong, Stephen Canman, Julie C. Stavropoulos, Nicholas Shirasu-Hiza, Mimi |
author_sort | Hill, Vanessa M. |
collection | PubMed |
description | Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep. |
format | Online Article Text |
id | pubmed-6042693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60426932018-07-19 A bidirectional relationship between sleep and oxidative stress in Drosophila Hill, Vanessa M. O’Connor, Reed M. Sissoko, Gunter B. Irobunda, Ifeoma S. Leong, Stephen Canman, Julie C. Stavropoulos, Nicholas Shirasu-Hiza, Mimi PLoS Biol Short Reports Although sleep appears to be broadly conserved in animals, the physiological functions of sleep remain unclear. In this study, we sought to identify a physiological defect common to a diverse group of short-sleeping Drosophila mutants, which might provide insight into the function and regulation of sleep. We found that these short-sleeping mutants share a common phenotype of sensitivity to acute oxidative stress, exhibiting shorter survival times than controls. We further showed that increasing sleep in wild-type flies using genetic or pharmacological approaches increases survival after oxidative challenge. Moreover, reducing oxidative stress in the neurons of wild-type flies by overexpression of antioxidant genes reduces the amount of sleep. Together, these results support the hypothesis that a key function of sleep is to defend against oxidative stress and also point to a reciprocal role for reactive oxygen species (ROS) in neurons in the regulation of sleep. Public Library of Science 2018-07-12 /pmc/articles/PMC6042693/ /pubmed/30001323 http://dx.doi.org/10.1371/journal.pbio.2005206 Text en © 2018 Hill et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Short Reports Hill, Vanessa M. O’Connor, Reed M. Sissoko, Gunter B. Irobunda, Ifeoma S. Leong, Stephen Canman, Julie C. Stavropoulos, Nicholas Shirasu-Hiza, Mimi A bidirectional relationship between sleep and oxidative stress in Drosophila |
title | A bidirectional relationship between sleep and oxidative stress in Drosophila |
title_full | A bidirectional relationship between sleep and oxidative stress in Drosophila |
title_fullStr | A bidirectional relationship between sleep and oxidative stress in Drosophila |
title_full_unstemmed | A bidirectional relationship between sleep and oxidative stress in Drosophila |
title_short | A bidirectional relationship between sleep and oxidative stress in Drosophila |
title_sort | bidirectional relationship between sleep and oxidative stress in drosophila |
topic | Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042693/ https://www.ncbi.nlm.nih.gov/pubmed/30001323 http://dx.doi.org/10.1371/journal.pbio.2005206 |
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